An analysis of the risk of B-lymphocyte malignancies in industrial cohorts

Journal of Toxicology and Environmental Health. Part a
John A BukowskiNancy C Wojcik

Abstract

Among numerous studies of occupational groups with varied chemical exposures (e.g., farmers, petroleum workers, and rubber workers), some have reported excess risk for non-Hodgkin's lymphoma (NHL), multiple myeloma, and other cancers of the B-lymphocyte cell line. While not conclusive, these studies raise questions about the effects of chemical exposures on the lymphocytic versus myeloid cell lines. Almost 70 occupational cohort studies were identified that addressed B-cell cancer risks in 9 major industrial categories, in order to look for common patterns across industries. This effort was substantially limited by the inconsistent nature of lymphohematopoietic (LH) classification schemes across studies and over time, and the relative paucity of B-cell-specific results in studies for any given industry. Taking these limitations into consideration, a descriptive, graphical analysis suggested a pattern of B-cell cancer elevations in the rubber and "general chemical" industries, but no consistent patterns in petroleum production/distribution or petrochemical production. The limited data sources, which lack detail about differences in hazard and exposure for different types of products/chemicals, did not allow a comprehensive look ...Continue Reading

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Citations

Sep 1, 2005·Cancer Causes & Control : CCC·Alexis DescathaJacques Ameille
Jan 15, 2005·Journal of Epidemiology and Community Health·E G Knox
Mar 16, 2006·Journal of Clinical Laboratory Analysis·Ugur DeligezerNejat Dalay
Jul 10, 2018·Journal of Occupational and Environmental Medicine·A Robert SchnatterElizabeth M Gallagher

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