PMID: 6970261Dec 1, 1980Paper

An analysis of tolazoline therapy in the critically-ill neonate

Journal of Pediatric Surgery
D C StevensT R Weber

Abstract

There were 47 seriously-ill neonates with medical causes of respiratory distress and 10 infants with severe respiratory distress secondary to a congenital diaphragmatic hernia treated with tolazoline according to a strict protocol designed to manage persistent fetal circulation (PFC). Of the 47 infants, 28 (60%) had a positive response defined as an increase in the pO2 greater than or equal to 24 mm Hg within 4 hr of beginning the drug. Of 7 infants, 4 with congenital diaphragmatic hernia had a positive response. The mean increase in the pO2 for the 47 infants was statistically significant (p less than .05). Of the 47 infants with medical disorders, 27 survived (survival 57%), whereas only 2 of the 10 infants with congenital diaphragmatic hernia and severe persistent fetal circulation survived (survival 28%). Erythema (60%), hematest positive gastric aspirates (55%), thrombocytopenia (45%), hyponatremia (40%) and increased gastric aspirates (36%) were the most common adverse effects occurring during tolazoline infusion. Hypotension occurred in nine cases, but was transient. Of the 27 survivors, 20 with medical causes of persistent fetal circulation were evaluated at age 1 yr. Eighty percent of these infants studied were conside...Continue Reading

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Citations

Nov 30, 2002·Paediatric Respiratory Reviews·Nicola P SmithPaul D Losty
May 1, 1984·Australian Paediatric Journal·W W ButtL J Murton
Sep 1, 1985·Archives of Disease in Childhood·R G WilsonP A Raine
Aug 1, 1988·British Heart Journal·A BushE A Shinebourne
Jul 1, 1993·Early Human Development·V Y Yu
Aug 1, 1994·Journal of Pediatric Surgery·N ShahR Simmons
May 1, 1987·Journal of Pediatric Surgery·J R Siebert, D R Benjamin
Aug 1, 1984·Journal of Pediatric Surgery·M ReynoldsR Lappen
Oct 1, 1983·The Journal of Pediatrics·W W Fox, S Duara
Apr 1, 1996·Journal of Cardiothoracic and Vascular Anesthesia·T S Lee, X Hou
Jul 1, 1991·The Australian and New Zealand Journal of Surgery·J M Benson, G Orlay
Nov 12, 2010·The Cochrane Database of Systematic Reviews·Dirk BasslerHaresh Kirpalani
Aug 1, 1986·Australian Paediatric Journal·W ButtA Duncan

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