An analysis of transfusion support in haematopoietic stem cell transplantation--report from a centre in India

Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis
Suvro Sankha DattaMammen Chandy

Abstract

Transfusion support in haematopoietic stem cell transplantation (HSCT) can be very demanding and challenging. The conditioning regimen, stem cell dose, donor type, presence of GvHD, infection all influence transfusion therapy in haematopoietic stem cell transplantation (HSCT). We retrospectively analysed the first 100 days transfusion requirements among HSCT recipients with haematological as well as non-haematological malignancies in our centre. Transfusion data were retrieved for 100 patients who had undergone HSCT over a period of two years. The HSCT recipients were divided into three groups: autologous, allogenic and haplo-identical. Allogenic group was subdivided into matched related donor (MRD) and matched unrelated donor (MUD). The allo and haplo groups were then classified on the basis of the ABO compatibility as major, minor, bi-directional and compatible. We analysed the mean requirement of blood components (RBC, RDP, SDP and FFP) within the first 100 days of HSCT in each category. Haematologic malignancies constituted 97% of the indications for HSCT. Allo-HSCT constituted 50% of the HSCT, of which 92% were MRD. Auto and haplo-HSCT constituted 40% and 10% respectively. Mean requirement for all products--RBC, SDP, RDP a...Continue Reading

References

Oct 1, 1978·Transplantation·C D BucknerE D Thomas
Jan 26, 1989·The New England Journal of Medicine·C AnasettiE Mickelson
Aug 5, 2000·Bone Marrow Transplantation·K K BallenP S Becker
May 7, 2002·Nature Reviews. Cancer·Marie-Térèse Little, Rainer Storb
Sep 9, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Karen K BallenPatricia A Ford
Dec 13, 2005·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Jörg D SeebachUNKNOWN GVHD Working Committee of Center for International Blood and Marrow Transplant Research

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