An analysis on the combination expression of HPV L1 capsid protein and p16INK4a in cervical lesions

Diagnostic Cytopathology
Min-Zhu HuangXiao-Man Jiang

Abstract

Human papillomavirus (HPV) infection in cervix is the most important reason for cervical cancer, but only 2% cervical HPV infection will develop into cervical cancer. So how to identify patients at risk of progressive cervical lesions from those infected with HPV to avoid over treatment is a big issue in clinic. The aims of this study were to detect the expression of HPV L1 capsid protein and p16(INK4a) in cervical lesions and to investigate the combination expression of HPV L1 capsid protein and p16(INK4a) in cervical lesions and its diagnostic efficiency in clinic. Immunochemical method was used to detect the expression of HPV L1 capsid protein and p16(INK4a) in 169 cases of abnormal cytology. Histopathologic test was performed to identify cervical lesions of all the cases. chi(2) test and spearman's rank correlation were used for statistical analysis. The diagnostic sensitivity, specificity, positive predictive values (PPV), negative predictive values (NPV), accuracy, and the area under the receive operating characteristic (ROC) curve (denoted by A(Z)) were calculated with SPSS 13.0. All the statistical tests were two sided at the 5% level of significance. L1 expression decreased (P < 0.001), but p16(INK4a) expression increa...Continue Reading

References

Apr 1, 1993·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·A G Ostör
Apr 6, 2001·International Journal of Cancer. Journal International Du Cancer·R KlaesM von Knebel Doeberitz
Jun 26, 2001·International Journal of Experimental Pathology·H R McMurrayD J McAnce
Oct 23, 2001·International Journal of Cancer. Journal International Du Cancer·D M ParkinP Pisani
Nov 1, 2002·The American Journal of Surgical Pathology·Rüdiger KlaesMagnus von Knebel Doeberitz
Mar 11, 2003·Transactions of the Royal Society of Tropical Medicine and Hygiene·R Sankaranarayanan
Mar 9, 2005·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·John Doorbar
Mar 12, 2005·CA: a Cancer Journal for Clinicians·D Max ParkinPaola Pisani
Aug 30, 2005·Acta Cytologica·Scott B CantorCalum MacAulay
Oct 13, 2005·Vaccine·Margaret Stanley
Nov 1, 2005·Yonsei Medical Journal·Young Tae Kim, Min Zhao
Jun 11, 2008·Applied Immunohistochemistry & Molecular Morphology : AIMM·Mohammad ArafaPhilippe Delvenne
Sep 5, 2008·The American Journal of Surgical Pathology·Giovanni NegriEduard Egarter-Vigl
Oct 10, 2008·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Kate Cuschieri, Nicolas Wentzensen

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Citations

Sep 22, 2012·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Anna YemelyanovaRichard B S Roden
Jul 28, 2010·The American Journal of Surgical Pathology·Mary T GalganoMark H Stoler
Oct 1, 2011·Future Microbiology·Vikrant V SahasrabuddheNicolas Wentzensen

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