PMID: 8971351Oct 1, 1996Paper

An analytical comparison of cobalt cardiomyopathy and idiopathic dilated cardiomyopathy

Biological Trace Element Research
J A CentenoR Virmani

Abstract

Toxic cardiomyopathy (TC) has a rapid clinical course and morphologically resembles idiopathic dilated cardiomyopathy (IDC). To further characterize TC, we used light microscopy to compare lesions caused by cobalt (Co) to those of IDC. Cobalt levels were also measured as a chemical marker to differentiate TC from IDC. We reviewed cases with TC and IDC and excluded all cases with chemotherapy-induced myopathy and catecholamine toxicity as well as cases with possible infectious, ischemic, or hypersensitivity-induced myopathies. We compared the light microscopic findings of 12 TC cases of 12 cases of IDC, and measured trace Co levels on digested heart tissue samples. The TC cases had prominent myofibrillar loss and atrophy; no cases had neutrophil infiltration or frank myocyte necrosis. In contrast, IDC had minimal myofibril loss and atrophy. Cobalt levels in the range of 0.6 to 5.45 micrograms/g of dry tissue were obtained for the TC cases, while IDC demonstrated Co levels of 0.01-0.2 micrograms/g. Distinction between TC and IDC is predominantly a function of myocyte change, with TC showing myofibrillar loss and atrophy in the absence of inflammatory infiltrates and fibrosis; IDC is predominantly associated with myocyte hypertrop...Continue Reading

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Citations

Feb 7, 2014·The New England Journal of Medicine·Larry A AllenEugene E Wolfel
Jun 26, 1999·Journal of Toxicology. Clinical Toxicology·D G Barceloux
Feb 14, 2006·Mayo Clinic Proceedings·Leslie T CooperDennis M McNamara
Jun 22, 2015·The Veterinary Journal·Ali Mobasheri, Christopher J Proudman
Mar 23, 2015·Current Treatment Options in Cardiovascular Medicine·Antonio L Perez, W H Wilson Tang
Jan 15, 2013·The Canadian Journal of Cardiology·Cameron J GilbertChristopher Overgaard
Nov 22, 2000·American Journal of Physiology. Heart and Circulatory Physiology·H EndohE Takahashi

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