An Analytical Model for Estimating Alveolar Wall Elastic Moduli From Lung Tissue Uniaxial Stress-Strain Curves

Frontiers in Physiology
Samer Bou JawdeBéla Suki

Abstract

The non-linear stress-strain behavior of uniaxially-stretched lung parenchyma is thought to be an emergent phenomenon arising from the ensemble behavior of its microscopic constituents. Such behavior includes the alignment and elongation of randomly oriented alveolar walls with initially flaccid fibers in the direction of strain. To account for the link between microscopic wall behavior and the macroscopic stress-strain curve, we developed an analytical model that represents both alignment and elongation of alveolar walls during uniaxial stretching. The model includes the kinetics and mechanical behavior of randomly oriented elastic alveolar walls that have a bending stiffness at their intersections. The alignment and stretch of the walls following incremental stretch of the tissue were determined based on energy minimization, and the total stress was obtained by differentiating the total energy density with respect to strain. The stress-strain curves predicted by the model were comparable to curves generated by a previously published numerical alveolar network model. The model was also fit to experimentally measured stress-strain curves in parenchymal strips obtained from mice with decreased lung collagen content, and from you...Continue Reading

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Citations

Aug 28, 2020·Tissue Engineering. Part a·Bahareh AzimiSerena Danti
Jul 1, 2021·Acta Biomaterialia·Jiawen ChenJinho Kim
Sep 30, 2021·Biomedical Materials·Gurpreet Singh, Arnab Chanda

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Methods Mentioned

BETA
pharmacotherapies
light scattering
rheology
atomic force microscopy
AFM

Software Mentioned

MATLAB
SigmaPlot
nlinfit

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