An ancient cytokine, astakine, mediates circadian regulation of invertebrate hematopoiesis.

Cellular and Molecular Life Sciences : CMLS
Apiruck WatthanasurorotIrene Söderhäll

Abstract

Invertebrate circulating hemocytes are key players in the innate immune defense and their continuous renewal from hematopoietic tissues is tightly regulated in crustaceans by astakine, a new family of cytokines sharing a prokineticin (PROK) domain. In vertebrates, brain PROKs function as transmitters of circadian rhythms and we present evidence that hemocyte release from hematopoietic tissues in crayfish is under circadian regulation, a direct result of rhythmic expression of astakine. We demonstrate that the observed variation in astakine expression has an impact on innate immunity assessed as susceptibility to a pathogenic Pseudomonas species. These findings enlighten the importance of comparing immune responses at fixed times not to neglect circadian regulation of innate immunity. Moreover, our results entail an evolutionary conserved function for prokineticins as mediators of circadian rhythm, and for the first time show a role for this domain in circadian regulation of hematopoiesis that may have implications also in vertebrates.

References

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Citations

May 3, 2013·Proceedings of the National Academy of Sciences of the United States of America·Gáspár Jékely
Mar 30, 2011·Blood·Xionghui Lin, Irene Söderhäll
Apr 5, 2013·PLoS Genetics·Apiruck WatthanasurorotIrene Söderhäll
Mar 19, 2013·Developmental and Comparative Immunology·Chadanat NooninIrene Söderhäll
Nov 3, 2015·Developmental and Comparative Immunology·Yiqun LiLinsheng Song
Aug 15, 2014·Developmental Cell·Jeanne L BentonBarbara S Beltz
Oct 9, 2014·Frontiers in Immunology·Kurt Buchmann
Jun 25, 2021·Scientific Reports·Fang LiFeng Yang
Aug 10, 2021·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Bo LiuChaohua Dong

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