An Androgen Receptor-positive Carcinoma of the Lacrimal Drainage System Resembling Salivary Duct Carcinoma: Case Report and Review of the Literature

Applied Immunohistochemistry & Molecular Morphology : AIMM
Siavash RahimiSolmaz Abdolrahimzadeh

Abstract

Carcinomas of the lacrimal drainage apparatus are rare and due to their aggressive behavior, they usually require extensive surgical treatment. We report a unique case of a 60-year-old man presenting with proptosis found to have a mass in the lacrimal drainage system on magnetic resonance imaging. Histology revealed a high-grade carcinoma with morphologic features of salivary gland duct carcinoma. Immunohistochemistry showed an extensive positive staining to androgen receptor. This is the first report of salivary gland-like duct carcinoma of the lacrimal drainage apparatus. Androgen receptor should be included in the immunohistochemical panel for the diagnostic work-up of lacrimal drainage system carcinomas, which resemble salivary gland duct carcinoma. This finding could have important diagnostic and therapeutic implications.

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Citations

Jan 14, 2017·Cancers·Michael T Schweizer, Evan Y Yu
Mar 2, 2018·International Journal of Cancer. Journal International Du Cancer·Eline BoonCarla M L van Herpen
May 19, 2020·Cancer Cytopathology·Masato NakaguroToshitaka Nagao
Jun 15, 2017·OTO Open : the Official Open Access Journal of the American Academy of Otolaryngology--Head and Neck Surgery Foundation·Siavash RahimiPeter A Brennan
Jan 12, 2021·Head and Neck Pathology·Abbas AgaimySimion I Chiosea
Apr 19, 2020·Survey of Ophthalmology·Ingvild RambergSteffen Heegaard

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Carcinoma, Ductal

Ductal carcinoma is a malignant neoplasm involving the ductal systems of any of a number of organs, such as the mammary glands, pancreas, prostate or lacrimal gland. Discover the latest research on ductal carcinoma here.

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