PMID: 9266695Jul 15, 1997

An angiogenic protein from bovine serum and milk--purification and primary structure of angiogenin-2

European Journal of Biochemistry
D J StrydomB L Vallee

Abstract

Bovine serum and milk contain a basic angiogenic protein that binds tightly to placental ribonuclease inhibitor. It was purified from both sources by ion-exchange and reversed-phase chromatographies. Its amino acid sequence revealed that it is a member of the ribonuclease superfamily. It contains 123 amino acids in a single polypeptide chain, is cross-linked by three disulfide bonds, is glycosylated at Asn33, and is 57% identical to bovine angiogenin. The amino-terminal and carboxyl-terminal residues are pyroglutamic acid and proline, respectively. The protein has ribonucleolytic activity that is similar to, but somewhat lower than, that of bovine angiogenin, i.e. very low relative to RNase. It is angiogenically potent on chicken chorioallantoic membrane, but less so than angiogenin. The sequence and activities demonstrate that this protein is a second, distinct, member of the angiogenin sub-family of pancreatic ribonucleases, and is referred to as angiogenin-2.

References

May 1, 1978·European Journal of Biochemistry·W GaastraJ J Beintema
Mar 1, 1977·British Journal of Cancer·D KnightonJ Folkman
Mar 1, 1977·British Journal of Haematology·D M Walford
Apr 1, 1976·European Journal of Biochemistry·J J BeintemaG W Welling
Mar 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·F Soncin
May 29, 1992·Biochemical and Biophysical Research Communications·E M KlenovaV V Lobanenkov
Apr 1, 1991·Analytical Biochemistry·J M CoullH Köster
Mar 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·T W HallahanB L Vallee
Jun 1, 1991·The Biochemical Journal·G R AdolfK Cantell
Apr 1, 1990·The Journal of Endocrinology·C A WilsonA J Chapman
Sep 24, 1990·Biochimica Et Biophysica Acta·L A Pinna
Sep 28, 1990·Biochemical and Biophysical Research Communications·M D Bond, B L Vallee
Apr 1, 1990·Journal of Biochemistry·K HosoyaM Irie
May 31, 1990·European Journal of Biochemistry·M TamburriniG D'Alessio
Jun 17, 1986·Biochemistry·R ShapiroB L Vallee
Oct 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·J W Harper, B L Vallee
Nov 1, 1989·Journal of Biochemistry·R NittaM Irie
Jul 1, 1989·Trends in Biochemical Sciences·J C Paulson
May 30, 1989·Biochemical and Biophysical Research Communications·F S Lee, B L Vallee
Jul 11, 1989·Biochemistry·M D Bond, D J Strydom
Sep 24, 1985·Biochemistry·D J StrydomB L Vallee
Jan 1, 1988·Progress in Biophysics and Molecular Biology·J J BeintemaA Carsana
Dec 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·R ShapiroB L Vallee
Jun 14, 1988·Biochemistry·J J BeintemaD G Glitz
Aug 1, 1988·Journal of Biochemistry·M IrieY Takizawa
Dec 5, 1988·FEBS Letters·P MaesA Tartar
Dec 1, 1988·Journal of Biochemistry·H WatanabeM Irie
Apr 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·R Shapiro, B L Vallee
Dec 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·D K St ClairB L Vallee
Aug 14, 1987·Biochemical and Biophysical Research Communications·S M RybakB L Vallee
Dec 2, 1985·European Journal of Biochemistry·J J BeintemaC Schüller
Jan 1, 1972·Annual Review of Biochemistry·R D Marshall
Nov 1, 1972·FEBS Letters·G D'AlessioE Leone
Jan 15, 1973·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·D J Strydom
Apr 14, 1972·Biochemical and Biophysical Research Communications·G D'AlessioE Leone
May 22, 1970·Biochemical and Biophysical Research Communications·L T Hunt, M O Dayhoff
Jan 1, 1984·Analytical Biochemistry·J J BeintemaD G Glitz
Dec 7, 1984·Journal of Chromatography·B A BidlingmeyerT L Tarvin
Aug 1, 1994·Nature Structural Biology·R J WoodsR A Dwek
Feb 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·G F HuB L Vallee
Oct 6, 1993·Biochimica Et Biophysica Acta·T P CurranB L Vallee
Mar 28, 1995·Proceedings of the National Academy of Sciences of the United States of America·K R AcharyaB L Vallee
Sep 30, 1994·Biochemical and Biophysical Research Communications·J Moroianu, J F Riordan
Mar 1, 1994·Proceedings of the National Academy of Sciences of the United States of America·J Moroianu, J F Riordan
Apr 12, 1994·Proceedings of the National Academy of Sciences of the United States of America·K R AcharyaB L Vallee
Apr 12, 1994·Proceedings of the National Academy of Sciences of the United States of America·N RussoB L Vallee
Jan 15, 1994·European Journal of Biochemistry·W ZhaoJ Hofsteenge
Dec 1, 1995·Journal of Molecular Evolution·E ConfaloneA Furia
Mar 18, 1996·FEBS Letters·N Trabesinger-RuefS A Benner
Apr 30, 1996·Proceedings of the National Academy of Sciences of the United States of America·V NobileR Shapiro
Sep 1, 1996·Genome Research·L D HillierM Marra

Citations

May 9, 2012·Journal of Molecular Evolution·Thomas T WheelerSandeep K Gupta
Jan 22, 2014·Nutrients·Miguel Ángel Medina, Ana R Quesada
Jan 5, 2010·BMB Reports·Seung Hwan JangHang Cheol Shin
Dec 11, 2013·Journal of Biomolecular Structure & Dynamics·Debi Ranjan TripathySwagata Dasgupta
Mar 29, 2002·Molecular Biology and Evolution·Jianzhi Zhang, H F Rosenberg
Sep 5, 2019·Nutrients·Beatriz Martínez-PovedaAna R Quesada

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