Dec 1, 1980

An animal model for assessing pain-on-injection of antibiotics

Journal of Pharmacological Methods
E CelozziA K Miller

Abstract

The paw-licking response of rats to a subplantar injection of an antibiotic was used as an indicator of the pain caused by that antibiotic. Good agreement with clinical findings was obtained with cefoxitin, cephalothin, cephradine, cefazolin, cephaloridine, and carbenicillin. Incorporation of a local anesthetic into the diluent of an irritating antibiotic reduced the number of paw-licking episodes. This rat paw model offers a simple and rapid means of estimating pain-on-injection following intramuscular injection of antibiotics to humans and may be applicable to other drugs as well.

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Mentioned in this Paper

Bacteriocidal Agents
Antibiotic throat preparations
Antifungal Antibiotics, Topical
Cephaloridine
Etiology
Carbenicillin
Local Anesthetic [EPC]
Antibiotics, Gynecological
Topical anesthetic
Antibiotics for systemic use

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