PMID: 3263827Jan 1, 1988Paper

An animal model for Lyme arthritis

Annals of the New York Academy of Sciences
S W BartholdA C Steere

Abstract

A model of Lyme arthritis has been developed in laboratory rats. Intraperitoneal inoculation of a low-passage tick isolate of B. burgdorferi into neonatal and weanling LEW/N rats resulted in multisystemic infection and arthritis. Spirochetes were isolated from blood, liver, kidney, spleen, brain, and joints of inoculated rats. Arthritis, associated with the presence of spirochetes, developed in multiple joints by day 14 and persisted through day 90 after inoculation. Arthritic lesions resembled those found in human Lyme disease lesions. Lesions were not found in other organs, although spirochetes were present. Neonatal F344 and SD rats were also susceptible to infection and induction of arthritis. Three different isolates of B. burgdorferi were shown to be pathogenic. Pathogenicity of one isolate was retained after at least 11 in vitro passages. Formalin-killed spirochetes were not pathogenic. Other features of the Lyme disease complex have yet to be seen in the rat, but long-term studies are required to completely define the rat model. This highly reproducible model should allow in-depth studies on the pathogenetic mechanisms of this important human disease.

References

Apr 1, 1988·The Journal of Infectious Diseases·S W BartholdA C Steere
Mar 1, 1986·The American Journal of Tropical Medicine and Hygiene·E C BurgessR Edelman
Jan 1, 1987·The American Journal of Tropical Medicine and Hygiene·J G DonahueA Spielman
Feb 1, 1986·Proceedings of the Society for Experimental Biology and Medicine·P H Duray, R C Johnson
Jul 1, 1985·Proceedings of the Society for Experimental Biology and Medicine·K I LokenR F Bey
May 1, 1984·The Journal of Infectious Diseases·J E CraftA C Steere
Oct 1, 1984·Infection and Immunity·A N KornblattD G Brownstein
Nov 1, 1984·The Journal of Infectious Diseases·J L BenachG S Habicht
Dec 1, 1984·Journal of Clinical Microbiology·R C JohnsonC Kodner
Apr 15, 1983·Science·E M BoslerA G Barbour
Jul 1, 1983·The American Journal of Tropical Medicine and Hygiene·J F AndersonA G Barbour
Jun 18, 1982·Science·W BurgdorferJ P Davis

❮ Previous
Next ❯

Citations

May 1, 1989·Trends in Neurosciences·A R Pachner
Dec 13, 2003·Proceedings of the National Academy of Sciences of the United States of America·Sukanya NarasimhanMelissa J Camaino
Nov 1, 1990·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·A Fox
Jan 16, 2007·Applied and Environmental Microbiology·Jon S BlevinsMichael V Norgard
Feb 8, 2005·Journal of Clinical Microbiology·Elizabeth S RavecheMadeleine W Cunningham
Apr 18, 2013·PLoS Pathogens·Juan C Garcia-Monco, Jorge L Benach
Feb 1, 1989·Seminars in Arthritis and Rheumatism·L H Sigal
Jan 3, 2006·Journal of Neuroimmunology·Libin LiAndrew R Pachner
Sep 1, 2011·European Journal of Microbiology & Immunology·M PásztóiE I Buzás
Aug 11, 2016·Proceedings of the National Academy of Sciences of the United States of America·Brandon Lyon JutrasChristine Jacobs-Wagner
Sep 7, 2004·Annals of Neurology·Andrew R PachnerDiego Cadavid
Nov 1, 1993·Infection and Immunity·S W SonnesynJ L Goodman
Jul 1, 1996·Infection and Immunity·B K Du ChateauR F Schell
May 1, 1993·Infection and Immunity·M S de SouzaS W Barthold
Mar 1, 1991·Microbiological Reviews·A Szczepanski, J L Benach

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Hereditary Sensory Autonomic Neuropathy

Hereditary Sensory Autonomic Neuropathies are a group of inherited neurodegenerative disorders characterized clinically by loss of sensation and autonomic dysfunction. Here is the latest research on these neuropathies.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Landau-Kleffner Syndrome

Landau Kleffner syndrome (LKS), also called infantile acquired aphasia, acquired epileptic aphasia, or aphasia with convulsive disorder, is a rare childhood neurological syndrome characterized by the sudden or gradual development of aphasia (the inability to understand or express language) and an abnormal electroencephalogram. Discover the latest research on LKS here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Regulation of Vocal-Motor Plasticity

Dopaminergic projections to the basal ganglia and nucleus accumbens shape the learning and plasticity of motivated behaviors across species including the regulation of vocal-motor plasticity and performance in songbirds. Discover the latest research on the regulation of vocal-motor plasticity here.