An animal model for small-diameter arterial grafts

Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research
W S CasselF Giron

Abstract

A rabbit model was developed to study small-diameter arterial grafts. A total of 158 2-mm-diameter polytetrafluoroethylene (PTFE) grafts and 35 autogenous carotid artery (AA) grafts were interposed in the carotid arteries of New Zealand white rabbits. A pilot study of 16 PTFE grafts used to develop operative and anesthetic techniques had a 20% mortality and 38% early (less than 2 day) thrombosis rate. Subsequent to the pilot study 177 grafts were placed and a 92% postoperative survival with 100% AA graft patency and 93% PTFE graft patency at 2 weeks was observed. AA grafts followed beyond 16 weeks continued to have 100% patency, while PTFE grafts began to show increased failure. Closure was found to be due to the development of anastomotic myointimal hyperplasia.

References

May 1, 1980·Journal of Microsurgery·D H LidmanR K Daniel

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Citations

Jun 19, 2013·Current Opinion in Biotechnology·Daniel D Swartz, Stelios T Andreadis
Mar 20, 2010·Journal of Vascular Surgery·Michael J ByromMartin K C Ng

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