An animal model of sensation seeking: the adolescent rat

Annals of the New York Academy of Sciences
Kirstie H StansfieldCheryl L Kirstein

Abstract

Previous research has established a strong relationship between a rodent's preference for novelty and sensitivity to psychomotor stimulants. Rats with greater sensitivity to the motoric effects of amphetamine exhibit higher preferences for novelty. Additionally, animals with high novelty preference scores are more easily drug conditioned and are more sensitive to, and can more accurately discriminate, amphetamine doses. Novelty preference in animals has been compared to sensation seeking in humans and is strongly correlated with drug use and addiction vulnerability. Thus, the present studies employed a playground maze procedure to measure changes in novelty preference across age following either four or eight habituation trials using eight distinct objects. Early-adult (postnatal day [PND] 59) animals did not exhibit a significant preference for a novel object regardless of total number of habituation trials. Early-adolescent animals (PND 34) exhibited a preference for the novel object in fewer than four habituation trials, but exhibited no preference with increased habituation trials. These results are counterintuitive and may demonstrate an overgeneralization of the habituation trials specific to adolescent animals. Given tha...Continue Reading

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Citations

Feb 7, 2012·Proceedings of the National Academy of Sciences of the United States of America·David A Sturman, Bita Moghaddam
Jan 28, 2012·Behavioural Brain Research·Michele L SaulJulie L Fudge
Apr 30, 2011·Neuroscience and Biobehavioral Reviews·David A Sturman, Bita Moghaddam
Nov 27, 2010·Pharmacology, Biochemistry, and Behavior·Iva Z MathewsCheryl M McCormick
Oct 1, 2008·Behavioural Brain Research·Jonathan WilliamsTerje Sagvolden
Oct 24, 2007·Behavioural Brain Research·Andrew T FoxMark P Reilly
Nov 14, 2006·Pharmacology, Biochemistry, and Behavior·Marc W FüllgrabeRainer Spanagel
Dec 3, 2008·The European Journal of Neuroscience·Terri L SchochetCharles F Landry
Dec 29, 2005·Developmental Psychobiology·Kirstie H Stansfield, Cheryl L Kirstein
Jun 30, 2006·Annals of Neurology·Kristopher J BoughRaymond J Dingledine
May 9, 2006·Behavioural Brain Research·A EnnaceurP L Chazot
Aug 23, 2005·Brain Research. Developmental Brain Research·Kirstie H Stansfield, Cheryl L Kirstein
Feb 19, 2013·Journal of Affective Disorders·Michele FornaroSalvatore Colicchio
Oct 23, 2013·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Marci R MitchellBarry Setlow

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