PMID: 11925307Apr 2, 2002Paper

An animal model of Tourette's syndrome

The American Journal of Psychiatry
Jane R TaylorPaul J Lombroso

Abstract

An animal model was used to investigate an autoimmune etiology for some cases of Tourette's syndrome. Sera from 12 patients with Tourette's syndrome with high levels of antineural or antinuclear antibodies were infused bilaterally into the ventrolateral striatum of rats. Sera from 12 additional Tourette's syndrome patients and 12 normal subjects (both groups with low levels of autoantibodies) were infused for comparison. Rates of oral stereotypies were recorded by observers who were blind to the origin of the infused sera. Oral stereotypies significantly increased in the rats infused with sera from the patients with high levels of autoantibodies. The results are consistent with an autoimmune etiology in a subset of cases of Tourette's syndrome.

Citations

Jun 21, 2007·Journal of Autism and Developmental Disorders·Nikki J KirkmanRobert S Fujinami
Jul 15, 2003·Current Psychiatry Reports·Joachim D K UysBrian H Harvey
Jun 8, 2011·Journal of Molecular Neuroscience : MN·Hilla Ben-PaziDaniel Offen
Mar 24, 2006·NeuroRx : the Journal of the American Society for Experimental NeuroTherapeutics·Lawrence ScahillJohn Walkup
Sep 11, 2003·Journal of Neuroimmunology·Pieter J HoekstraRuud B Minderaa
Apr 18, 2003·Pediatric Neurology·Christopher R LoiselleHarvey S Singer
Oct 8, 2008·Development and Psychopathology·Tiago V MaiaBradley S Peterson
Apr 27, 2012·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Lior BrimbergDaphna Joel
Jun 24, 2004·Archives of Disease in Childhood·A J ChurchG Giovannoni
Apr 3, 2009·The Journal of Clinical Investigation·Simran K Kalra, Susan E Swedo
Dec 7, 2002·CNS Drugs·Gin S MalhiShahzad Salim
Nov 22, 2002·Lancet·James F Leckman
Feb 25, 2014·Brain, Behavior, and Immunity·Dafna LotanDaphna Joel
Feb 11, 2011·Current Infectious Disease Reports·Sheila Knupp Feitosa de Oliveira, Christina Feitosa Pelajo
Oct 11, 2005·Journal of Biomedical Science·Chin-Bin YehJames F Leckman
Jan 7, 2015·Proceedings of the National Academy of Sciences of the United States of America·Meiyu XuChristopher Pittenger
Oct 17, 2007·Brain & Development·Paul J Lombroso, Lawrence Scahill
Mar 10, 2005·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Susan E Swedo, Paul J Grant
Nov 23, 2006·Journal of Psychiatric Research·Astrid MorerFrancesc Graus
Apr 20, 2016·Frontiers in Neuroscience·Ester NespoliAndrea G Ludolph
Jan 15, 2013·Neuroscience and Biobehavioral Reviews·Mady Hornig, W Ian Lipkin
May 23, 2014·Brain Research·Davide MartinoMaura Buttiglione
Jul 16, 2016·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Borwin BandelowPeter Riederer
Jan 17, 2017·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Xiuling YangTang Li
May 12, 2005·Journal of Neuroimmunology·Gavin Giovannoni
Sep 15, 2006·Journal of Child Neurology·Kendra Harris, Harvey S Singer
Dec 19, 2003·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Yi HuangDavid Collier
Apr 2, 2004·Nature·Richard A GibbsUNKNOWN Rat Genome Sequencing Project Consortium
Apr 13, 2004·Movement Disorders : Official Journal of the Movement Disorder Society·Roger Kurlan
Sep 25, 2004·Movement Disorders : Official Journal of the Movement Disorder Society·Mark J EdwardsKailash P Bhatia
Jul 9, 2004·Molecular Psychiatry·L A Snider, S E Swedo
Jul 13, 2004·Current Opinion in Neurology·Davide Martino, Gavin Giovannoni
Apr 13, 2004·Movement Disorders : Official Journal of the Movement Disorder Society·Christopher R LoiselleHarvey S Singer
Apr 13, 2004·Movement Disorders : Official Journal of the Movement Disorder Society·Harvey S SingerFranz H Grus
May 16, 2007·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Lisa LitFrank R Sharp
Mar 5, 2005·Movement Disorders : Official Journal of the Movement Disorder Society·Antonio L TeixeiraFrancisco Cardoso
Aug 3, 2007·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·D M MirandaC L Barr
Apr 9, 2009·Movement Disorders : Official Journal of the Movement Disorder Society·Davide MartinoJames F Leckman
Sep 24, 2005·Journal of Biomedical Optics·Takashi Murakami, Eiji Kobayashi
Jul 19, 2003·Current Opinion in Neurology·Tamara PringsheimAnthony Lang

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