An anionic shell shields a cationic core allowing for uptake and release of polyelectrolytes within core-shell responsive microgels

Soft Matter
Arjan P H GelissenWalter Richtering

Abstract

To realize carriers for drug delivery, cationic containers are required for anionic guests. Nevertheless, the toxicity of cationic carriers limits their practical use. In this study, we investigate a model system of polyampholyte N-isopropylacrylamide (NIPAM)-based microgels with a cationic core and an anionic shell to study whether the presence of a negative shell allows the cationic core to be shielded while still enabling the uptake and release of the anionic guest polyelectrolytes. These microgels are loaded with polystyrene sulfonate of different molecular weights to investigate the influence of their chain length on the uptake and release process. By means of small-angle neutron scattering, we evaluate the spatial distribution of polystyrene sulfonate within the microgels. The guest molecules are located in different parts of the core-shell microgels depending on their size. By combining these scattering results with UV-vis spectroscopy, electrophoretic mobility and potentiometric titrations we gain complementary results to investigate the uptake and release process of polyelectrolytes in polyampholyte core-shell microgels. Moreover, Brownian molecular dynamic simulations are performed to compare the experimental and theo...Continue Reading

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Citations

Dec 13, 2018·Physical Chemistry Chemical Physics : PCCP·Lars WiehemeierTilman Kottke
Feb 2, 2019·Soft Matter·Jonas LandsgesellPeter Košovan
Nov 19, 2019·Macromolecular Rapid Communications·Sarah K WypysekWalter Richtering
Sep 29, 2019·Critical Reviews in Analytical Chemistry·Muhammad ShahidAhmad Irfan
Jun 23, 2020·Structural Dynamics·S PasiniO Holderer
Nov 30, 2019·Langmuir : the ACS Journal of Surfaces and Colloids·Steffen BochenekWalter Richtering
May 28, 2020·Biomacromolecules·Victoria K SwitaczWalter Richtering
Dec 10, 2020·Advances in Colloid and Interface Science·Manuel Quesada-Pérez, Alberto Martín-Molina
Apr 4, 2021·Polymers·Marco AnnegarnThomas Hellweg
Jan 15, 2020·The Journal of Physical Chemistry. B·Ivan V Portnov, Igor I Potemkin
Oct 5, 2019·Langmuir : the ACS Journal of Surfaces and Colloids·Vittoria ChimissoWolfgang Meier
Apr 19, 2019·Langmuir : the ACS Journal of Surfaces and Colloids·Matthias KargWalter Richtering
Jul 13, 2019·Langmuir : the ACS Journal of Surfaces and Colloids·Haruka MinatoDaisuke Suzuki
Oct 24, 2019·Nano Letters·Laura Hoppe AlvarezDominik Wöll

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Methods Mentioned

BETA
dynamic light scattering
NMR
SANS

Software Mentioned

LAMMPS

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