An antagonist of lipid A action in mammals has complex effects on lipid A induction of defence responses in the model plant Arabidopsis thaliana

Microbes and Infection
Gitte ErbsM A Newman

Abstract

Lipopolysaccharides, the ubiquitous part of the outer membrane of Gram-negative bacteria, and their derivatives are recognised by plants to trigger or potentiate particular defence responses such as induction of genes encoding pathogenesis-related proteins. The molecular mechanisms of LPS perception that underpin these effects in plants are, however, unknown. Here, lipid A from Halomonas magadiensis, which is an antagonist of lipid A action in human cells, was used to investigate lipid A action in plants. Our findings offer an insight into the different structural requirements for direct induction and potentiation of plant defences by lipid A.

References

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Jul 11, 2007·Journal of Endotoxin Research·Mari-Anne NewmanMichelangelo Parrilli

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Citations

Jun 9, 2016·Scientific Reports·Sayaka IizasaYukio Nagano

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