An anti-HBV anthraquinone from aciduric fungus Penicillium sp. OUCMDZ-4736 under low pH stress

Extremophiles : Life Under Extreme Conditions
Yanzheng JinYi Wang

Abstract

To obtain new bioactive natural products, the effect of acidic stress on the metabolites of an aciduric fungus was investigated. This fungus, Penicillium sp. OUCMDZ-4736, which was isolated from the sediment around roots of mangrove (Acanthus ilicifolius), produced different compounds and higher yields under pH 2.5 than under neutral conditions. Using spectroscopic analyses and calculations, three new anthraquinone derivatives (1-3) were isolated and identified from the acidic fermentation broth (pH 2.5) of OUCMDZ-4736. Compound 1 showed much stronger anti-hepatitis B virus activity than that of the positive control, lamivudine, strongly inhibiting HBsAg and HBeAg secretion from HepG2.2.15 cells. These results show that extremophiles are a valuable resource of bioactive compounds, and that pH regulation is an effective strategy to induce metabolite production in aciduric fungi.

References

Dec 3, 1999·Applied and Environmental Microbiology·R S RedmanR Rodriguez
May 10, 2002·Nature·Linda A Amaral ZettlerMitchell L Sogin
Sep 25, 2009·Chemistry : a European Journal·Karsten KrohnBarbara Schulz
Nov 28, 2012·Nature Reviews. Microbiology·Axel A Brakhage

❮ Previous
Next ❯

Citations

Aug 15, 2019·Phytotherapy Research : PTR·Mohammad K ParvezAli S Alqahtani
Feb 7, 2020·Natural Product Reports·Anthony R CarrollMichèle R Prinsep
Feb 6, 2020·Applied Microbiology and Biotechnology·Muhammad IbrarFariha Hasan
Nov 18, 2020·Toxins·Marco Masi, Antonio Evidente
Feb 9, 2021·Frontiers in Microbiology·Hai GaoYi Wang
Nov 23, 2020·Archives of Pharmacal Research·Yun-Fei TengChang-Lun Shao
Oct 9, 2021·Natural Product Reports·Senhua ChenZhigang She

❮ Previous
Next ❯

Datasets Mentioned

BETA
KY848519

Methods Mentioned

BETA
column chromatography
enzyme-linked immunosorbent assay
ELISA
NMR

Related Concepts

Related Feeds

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.