PMID: 1211307Oct 1, 1975Paper

An anti-inflammatory substance in normal human plasma

Agents and Actions
M J Smith, A W Ford-Hutchinson

Abstract

A substance of low molecular weight, below 1000 daltons, has been separated from normal human plasma by a stepwise process involving ultrafiltration followed by column chromatography. The spectrum of anti-inflammatory activity of the active fraction in a variety of animal models shows that it is most active in situations in which the emigration of circulating leucocytes plays the more prominent role. The fraction exerts a selective action on the release of chemotactic factors after the activation in vitro of the complement cascade by the alternate but not by the classical pathway. The existence of the plasma fraction raises several interesting queries. Is it part of the naturally occurring control mechanisms in inflammation? What is its relevance to human disease, e.g., rheumatoid arthritis, and do conventional antirheumatic drugs interact with it? Does its lack of activity against chemical mediators of inflammation and their generating systems throw any light on the importance of these materials in inflammatory reactions?

References

Feb 1, 1975·The Journal of Pharmacy and Pharmacology·A W Ford-HutchinsonJ R Walker
Oct 1, 1975·The Journal of Pharmacy and Pharmacology·J R WalkerF J Billimoria
Jan 1, 1974·Annals of the New York Academy of Sciences·P A Ward
Nov 1, 1973·The Journal of Pharmacy and Pharmacology·A W Ford-HutchinsonM J Smith
Aug 1, 1974·The Journal of Pharmacy and Pharmacology·J P BolamM J Smith
Sep 1, 1974·The Journal of Pharmacy and Pharmacology·P N ElliottM J Smith
Oct 1, 1974·The Journal of Pharmacy and Pharmacology·M J SmithA W Ford-Hutchinson
Nov 1, 1974·The Journal of Pharmacy and Pharmacology·A W Ford-HutchinsonM J Smith
Jan 1, 1972·Annual Review of Medicine·A Janoff
Oct 1, 1971·The Journal of Pharmacy and Pharmacology·M J Smith, P D Dawkins
Feb 1, 1974·British Journal of Pharmacology·P N ElliottM J Smith
Oct 23, 1971·British Medical Journal·J N McArthurE B Hamilton
Jun 19, 1971·British Medical Journal·J N McArthurE B Hamilton

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Citations

Sep 1, 1976·Agents and Actions·J R WalkerA W Ford-Hutchinson
Nov 1, 1976·Agents and Actions·M J SmithD G Penington
Oct 1, 1976·The Journal of Pharmacy and Pharmacology·J R WalkerA W Ford-Hutchinson
Oct 1, 1976·The Journal of Pharmacy and Pharmacology·A W Ford-HutchinsonJ R Walker

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