An antiallergic activity of disodium cromoglycate unrelated to mast cell activation

Agents and Actions
K KuriyamaK Ito

Abstract

The pharmacological effects of disodium cromoglycate (DSCG) were studied in rats during the development of reactions to various allergens or carrageenin. DSCG (10 mg/kg and 100 mg/kg, i.v.) showed pronounced inhibitory effects on type I and type III (passive Arthus) allergic reactions. An immunological degranulation of mast cells and a significant decrease in tissue histamine content were observed in type I allergic reactions but not in type III allergic reactions characterized by an apparent infiltration of neutrophils. An antihistaminic agent, promethazine (1 mg/kg, i.v.) was effective only against type I allergic reactions and totally ineffective against type III allergic reactions. Thus, the results obtained above strongly suggest that DSCG exhibits at least two mechanisms of antiallergic action; one is related to mediator release from mast cells and the other is unrelated to mast cell activation.

Citations

Jan 1, 1970·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·A KodaH Wada
Nov 1, 1965·The Journal of Allergy·J J Ouellette, C E Reed
Nov 7, 1970·British Medical Journal·H PoppiusA Viljanen
Sep 7, 1968·British Medical Journal·S E Davies
Oct 1, 1981·Journal of Pharmacobio-dynamics·K Kuriyama, T Okuno
Aug 1, 1964·The Journal of Experimental Medicine·P G QUIE, J G HIRSCH

Related Concepts

Histamine Measurement
Vicrom
Mast Cell
Immediate Hypersensitivity
August Rats
Neutrophils as Percentage of Blood Leukocytes (Lab Test)
Immune Sera
Antihistamine [EPC]
Carrageenan
Allergens

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