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An antidepressant mechanism of desipramine is to decrease tumor necrosis factor-alpha production culminating in increases in noradrenergic neurotransmission

Neuroscience

Jan 1, 2005

Jessica L ReynoldsRobert Nicholas Spengler

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Abstract

The monoamine theory of depression proposes decreased bioavailability of monoamines, such as norepinephrine (NE), as the underlying cause of depression. Thus, the antidepressant efficacy of NE-reuptake inhibitors such as desipramine is attributed to increases in synaptic concentrations ...read more

Mentioned in this Paper

GTP-Binding Proteins
Anser species
Tumor Necrosis Factor Production
Respiratory, Thoracic and Mediastinal Disorders
Behavior, Animal
Desipramine
Neural Inhibition
Recombinant Tumor Necrosis Factor Family Protein
Freezing Reaction, Cataleptic
Isoglaucon
1
30
Paper Details
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  • Citations31
123
  • References30
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An antidepressant mechanism of desipramine is to decrease tumor necrosis factor-alpha production culminating in increases in noradrenergic neurotransmission

Neuroscience

Jan 1, 2005

Jessica L ReynoldsRobert Nicholas Spengler

PMID: 15878644

DOI: 10.1016/j.neuroscience.2005.02.023

Abstract

The monoamine theory of depression proposes decreased bioavailability of monoamines, such as norepinephrine (NE), as the underlying cause of depression. Thus, the antidepressant efficacy of NE-reuptake inhibitors such as desipramine is attributed to increases in synaptic concentrations ...read more

Mentioned in this Paper

GTP-Binding Proteins
Anser species
Tumor Necrosis Factor Production
Respiratory, Thoracic and Mediastinal Disorders
Behavior, Animal
1
30

Similar Papers Found In These Feeds

Related Papers

Paper Details
References
  • References30
  • Citations31
123
  • References30
  • Citations31
1234

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