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An antidepressant mechanism of desipramine is to decrease tumor necrosis factor-alpha production culminating in increases in noradrenergic neurotransmission

Neuroscience

May 10, 2005

Jessica L ReynoldsR N Spengler

Abstract

The monoamine theory of depression proposes decreased bioavailability of monoamines, such as norepinephrine (NE), as the underlying cause of depression. Thus, the antidepressant efficacy of NE-reuptake inhibitors such as desipramine is attributed to increases in synaptic concentrations ...read more

Mentioned in this Paper

Yohimbin Spiegel
Swimming
Behavior, Animal
ratio-Desipramine
Exertion
Tissue Membrane
Amines
Tumor Necrosis Factor-alpha
Neurotransmitter Secretion
Neural Inhibition
1
30
Paper Details
References
  • References30
  • Citations31
123
  • References30
  • Citations31
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An antidepressant mechanism of desipramine is to decrease tumor necrosis factor-alpha production culminating in increases in noradrenergic neurotransmission

Neuroscience

May 10, 2005

Jessica L ReynoldsR N Spengler

PMID: 15878644

DOI: 10.1016/j.neuroscience.2005.02.023

Abstract

The monoamine theory of depression proposes decreased bioavailability of monoamines, such as norepinephrine (NE), as the underlying cause of depression. Thus, the antidepressant efficacy of NE-reuptake inhibitors such as desipramine is attributed to increases in synaptic concentrations ...read more

Mentioned in this Paper

Yohimbin Spiegel
Swimming
Behavior, Animal
ratio-Desipramine
Exertion
Tissue Membrane
Amines
Tumor Necrosis Factor-alpha
Neurotransmitter Secretion
Neural Inhibition
1
30

Similar Papers Found In These Feeds

Limbic System

The limbic system is comprised of several different parts of the brain involved in emotion, motivation, learning, and memory. Discover the latest research on the limbic system here.

Functional Connectivity Networks

Functional connectivity networks represent specific patterns of synchronous activity and differ between healthy subjects, stages of consciousness and across disease. Discover the latest research on functional connectivity networks here.

Related Papers

Paper Details
References
  • References30
  • Citations31
123
  • References30
  • Citations31
1234
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