An antigen expressed by murine CD8+ T cells and activated B cells

Immunobiology
M BreelG Kraal

Abstract

A monoclonal antibody, H1F5, is described that reacts with a subset of Lyt-2 (CD8) mouse T cells and LPS-activated B cells. In both lymph nodes and spleen of BALB/c mice, the H1F5 antigen is coexpressed approximately on 20%-30% of the CD8+ T cells and approximately on 91% of LPS-activated B cells. In the thymus, few cells (less than 1%) are positive for the marker, but no correlation could be demonstrated with markers for mature T cells such as MEL-14 and PNA expression. Elimination of H1F5+ cells by complement lysis led to a 30%-50% reduction of specific lysis as measured in a primary allo CTL, indicating that the cytotoxic effector cells are injured. The relationship of this marker and other antigenic determinants on lymphocytes is discussed.

References

Jan 1, 1979·Immunological Reviews·J A Ledbetter, L A Herzenberg
Feb 1, 1986·The Journal of Experimental Medicine·K L RockB Benacerraf
Feb 24, 1984·Journal of Immunological Methods·W S WalkerS E Yen
Jan 1, 1984·Immunogenetics·P M HogarthI F McKenzie

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