An antimalarial tetrapeptide from the entomopathogenic fungus Hirsutella sp. BCC 1528

Journal of Natural Products
Jiraporn ThongtanMasahiko Isaka

Abstract

Hirsutellic acid A (1), a new linear tetrapeptide possessing an anthranilic acid residue at the C-terminus, was isolated from a fermentation broth of the entomopathogenic fungus Hirsutella sp. BCC 1528. The structure of this compound was elucidated by NMR and MS analyses, and its absolute configuration was deduced by HPLC analysis of the acid hydrolysate using a chiral column. Hirsutellic acid A exhibits activity against the malarial parasite Plasmodium falciparum K1 with an IC(50) value of 8.0 microM, while it was noncytotoxic to Vero cells at a concentration of 95 microM.

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Citations

Nov 18, 2014·Parasite : Journal De La Société Française De Parasitologie·Shweta SinhaRakesh Sehgal
Dec 25, 2009·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Lemuel Pérez-PicasoMaría Yolanda Rios
May 16, 2020·Journal of Fungi·Xiaoyan NiuQiongbo Hu
Feb 29, 2008·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Manisha SatheMahabir Parshad Kaushik
May 30, 2020·Chembiochem : a European Journal of Chemical Biology·Felix SchalkChristine Beemelmanns
May 12, 2018·Applied Microbiology and Biotechnology·Juliana LenziLorena Benathar Ballod Tavares

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