An Antimicrobial Peptide-Loaded Gelatin/Chitosan Nanofibrous Membrane Fabricated by Sequential Layer-by-Layer Electrospinning and Electrospraying Techniques

Nanomaterials
Yuzhu HeHuiying Liu

Abstract

Guided bone regeneration (GBR) technique is widely used in the treatment of bone defects caused by peri-implantitis, periodontal disease, etc. However, the GBR membranes commonly used in clinical treatments currently have no antibacterial activity. Therefore, in this study, sequential layer-by-layer electrospinning and electrospraying techniques were utilized to prepare a gelatin (Gln) and chitosan (CS) composite GBR membrane containing hydroxyapatite nanoparticles (nHAp) and antimicrobial peptide (Pac-525)-loaded PLGA microspheres (AMP@PLGA-MS), which was supposed to have osteogenic and antibacterial activities. The scanning electron microscope (SEM) observation showed that the morphology of the nanofibers and microspheres could be successfully produced. The diameters of the electrospun fibers with and without nHAp were 359 ± 174 nm and 409 ± 197 nm, respectively, and the mechanical properties of the membrane were measured according to the tensile stress-strain curve. Both the involvement of nHAp and the chemical crosslinking were able to enhance their tensile strength. In vitro cell culture of rat bone marrow mesenchymal stem cells (rBMSCs) indicated that the Gln/CS composite membrane had an ideal biocompatibility with good c...Continue Reading

References

Jul 24, 2002·Biochemistry·Gunnar FimlandJon Nissen-Meyer
Nov 21, 2002·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·David J SchibliRichard M Epand
Dec 29, 2005·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Thami Sebti, Karim Amighi
Jun 20, 2008·Journal of Biomedical Materials Research. Part a·Shen ZhangXuliang Deng
Jul 7, 2010·Biochemical and Biophysical Research Communications·Xiaobao QiMary B Chan-Park
Jun 10, 2011·Bio-medical Materials and Engineering·Javad JafariFazel Gorjipour
Sep 21, 2011·Nanomedicine·Elizabeth HoodVladimir Muzykantov
Jun 12, 2013·Macromolecular Bioscience·Milena IgnatovaIliya Rashkov
Apr 16, 2014·Journal of Biomedical Materials Research. Part a·Wen ZhaoYing Wang
Dec 11, 2014·Materials Science & Engineering. C, Materials for Biological Applications·Dan KaiXian Jun Loh
Sep 30, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yuanyuan LiFuzhai Cui
Oct 25, 2017·The Journal of Oral Implantology·Anna JoopMarcus Stoetzer
Dec 23, 2017·Peptides·Pengchao ZhaoFengshou Zhang
Jan 23, 2018·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Weilu ChengYudong Huang

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Citations

Jul 25, 2019·Macromolecular Bioscience·Alexander DartPeter Kingshott
Jul 30, 2019·Frontiers in Chemistry·Yu ZhuangHongbo Yu
Jun 18, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Andrew W SimonsonScott H Medina
Sep 5, 2019·Pharmaceutics·Ángela Martin-SerranoF Javier de la Mata
Nov 25, 2020·International Journal of Biological Macromolecules·Feifei LiuYingbo Wang
Jan 1, 2020·Carbohydrate Polymers·Fenghua TaoHongbing Deng
Dec 31, 2020·Pharmaceutics·Ane EscobarSergio Enrique Moya
Mar 21, 2021·Drug Discovery Today·Maurício G C SousaOctávio L Franco
Jul 1, 2020·International Journal of Biological Macromolecules·Elaheh FakhriHossein Samadi Kafil
Mar 27, 2021·Drug Delivery and Translational Research·Sevda ŞenelGülçin Akca
Jun 7, 2021·Colloids and Surfaces. B, Biointerfaces·Peiyi LiXinchun Zhang
Aug 29, 2021·Pharmaceuticals·Gustavo MoraesWalter L Siqueira
Sep 4, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Xinyu SongZhiyu He

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