An antioxidant-like action for non-peroxidisable phospholipids using ferrous iron as a peroxidation initiator

Biochimica Et Biophysica Acta
Colin H Cortie, Paul L Else

Abstract

The degradation of phospholipids containing polyunsaturated fatty acids, termed peroxidation, poses a constant challenge to membranes lipid composition and function. Phospholipids with saturated (e.g. PC 16:0/16:0) and monounsaturated fatty acids (e.g. PC 16:0/18:1) are some of the most common phospholipids found in membranes and are generally not peroxidisable. The present experiments show that these non-peroxidisable phospholipids, when present in liposomes with peroxidisable phospholipids (i.e. those containing polyunsaturated fatty acids) such as PC 16:0/18:2 and Soy PC, produce an inhibitory effect on rates of peroxidation induced by ferrous-iron. This inhibitory effect acts to extend the duration of the lag phase by several-fold. If present in natural systems, this action could enhance the capacity of conventional antioxidant mechanisms in membranes. The results of this preliminary work suggest that non-peroxidisable phospholipids may exert an antioxidant-like action in membranes.

References

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Jan 25, 2012·Lipids·Sarah E NorrisPaul L Else
Dec 18, 2013·Chemistry and Physics of Lipids·Ilya Pinchuk, Dov Lichtenberg

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Citations

Dec 29, 2020·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Paul L Else

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