PMID: 8597428Dec 29, 1995Paper

An antistress and antiaging neurometabolic therapy. Accelerated lipofuscinolysis and stimulated anabolic regeneration by the antagonic-stress synergistic formula

Annals of the New York Academy of Sciences
S Riga, D Riga

Abstract

In both stress and aging, an etiopathogenic analysis demonstrates in the brain some common mechanisms and reciprocal accelerating relationships: hypoanabolism (decrease of RNA and protein synthesis), coupled with hypercatabolism (increase of oxidative stress-lipid peroxidation, with waste product accumulation: lipofuscinage pigment and water-insoluble proteins). For therapeutical intervention in these antihomeostatic processes, we successively (1972-1992) developed a neurometabolic antioxidative therapy--finally represented by a specific antistress and antiaging synergistic formula, Antagonic-Stress. Its homeostatic actions have been demonstrated in the stressed aging brains by reestablishing the anabolism/catabolism balance: anabolic regeneration by increasing total RNA, total proteins and water-soluble proteins, coupled with catabolic regulation by accelerated lipofuscinolysis and age pigment elimination (neuronal-->glial-->capillary route) and decreasing of water-insoluble proteins. Specific, synergistic, and superior actions of Antagonic-Stress multiple formula vs. antistress and antiaging monotherapy have been demonstrated by preclinical and clinical studies, confirming our results.

References

Jan 1, 1977·RöFo : Fortschritte auf dem Gebiete der Röntgenstrahlen und der Nuklearmedizin·A HartmannW Dorndorf
Feb 1, 1978·Journal of the American Geriatrics Society·K Nandy
May 1, 1992·Italian Journal of Neurological Sciences·M MazzoniP Moretti
Jan 1, 1990·Annual Review of Neuroscience·C E Finch, D G Morgan
Jan 1, 1989·Advances in Experimental Medicine and Biology·R S Sohal, U T Brunk
Sep 1, 1987·Cleveland Clinic Journal of Medicine·Z B ArgenyiJ S Taylor
Mar 1, 1988·Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics·S Kondo
Oct 1, 1986·Physiology & Behavior·J P Kroon, A L Riley
Jul 1, 1972·The Histochemical Journal·D Hopwood
Jul 1, 1974·Postgraduate Medical Journal·F W SmithM MacLeod
Jan 1, 1970·Journal of Ultrastructure Research·S O Bohman, A B Maunsbach
Jan 1, 1980·The International Journal of Biochemistry·G Hocman
Jun 30, 1994·Annals of the New York Academy of Sciences·V PredescuL Botezat-Antonescu
Jun 30, 1994·Annals of the New York Academy of Sciences·F SchneiderR Mateescu
Jan 1, 1960·Journal of Gerontology·N M SULKIN, P SRIVANIJ
Nov 21, 1964·Nature·J M ORDYR L COLLINS
Mar 1, 1991·Archives of Gerontology and Geriatrics·E A Porta
Jan 1, 1991·Archives of Gerontology and Geriatrics·Z KristofikováH Tejkalová
Jan 1, 1994·Archives of Gerontology and Geriatrics·R PopaR Mateescu

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