PMID: 5905239Feb 1, 1966

An antiviral substance from Penicillium funiculosum. IV. Inquiry into the mechanism by which helenine exerts its antiviral effect

The Journal of Experimental Medicine
R E Shope

Abstract

1. Helenine injected intraperitoneally 24 hr prior to a regularly fatal dose of Semliki Forest virus saves most of the mice to which it is administered. 2. Mice saved by helenine develop no viral immunity and regularly succumb when rechallenged 2 wk later with the same dose of virus from which they were originally saved. 3. The time during which helenine is optimally effective in protecting mice from death by Semliki Forest virus covers a period of approximately 36 hr beginning after about 12 hr and extending to 48 hr before virus infection. When periods of less than 12 hr, or more than 48 hr, elapse between the time of helenine administration and virus inoculation, its protective effectiveness diminishes progressively. 4. Repeated injections of helenine at 2- or 3-day intervals, if continued long enough, exhaust the capacity of a host to respond favorably to helenine administered 24 hr before virus inoculation. 5. Helenine injections at intervals of 4, 3, and 2 wk before its administration 24 hr prior to infection do not decrease the effectiveness of this final dose in protecting mice from fatal infection by the virus. The experimental results here reported indicate that, as suggested by the findings of earlier work, helenine ...Continue Reading

References

Sep 1, 1964·Proceedings of the National Academy of Sciences of the United States of America·W J KLEINSCHMIDTE B MURPHY

Citations

Aug 1, 1967·Proceedings of the National Academy of Sciences of the United States of America·G P LampsonM R Hilleman
Apr 1, 1966·The Journal of Experimental Medicine·M W RytelE D Kilbourne
Feb 1, 1972·CRC Critical Reviews in Biochemistry·A A Tytell, A K Field
Jul 1, 1970·Angewandte Chemie·Y K Murthy, H P Anders
Aug 26, 2006·Cytokine & Growth Factor Reviews·A Billiau
Feb 1, 1968·Journal of Cellular Physiology·M R Hilleman

Related Concepts

Antiviral Agents
Arbovirus Infections
Penicillium
Semliki forest virus

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