PMID: 8939459Nov 1, 1996Paper

An AP-1 site is involved in the NGF induction of IL-1 alpha in PC12 cells

Neurochemistry International
K AlheimT Bartfai

Abstract

The nerve growth factor which induces phenotypic changes in PC12 pheochromocytoma cells also induces the expression of the proinflammatory cytokine interleukin 1 alpha in these cells. We have studied the signal transduction and transcriptional mechanisms involved in this induction of interleukin 1 alpha by nerve growth factor. The nerve growth factor induction of interleukin 1 alpha transcription in PC12 cells is exerted via the TrkA receptor, as demonstrated by inhibition of the nerve growth factor stimulated increases in the interleukin 1 alpha mRNA levels by the TrkA specific alkaloid K-252a. The promoter region(s) involved in induction of interleukin 1 alpha expression by nerve growth factor in PC12 pheochromocytoma cells were studied by deletion mutagenesis in a part of the 5' regulatory region of the human interleukin 1 alpha gene (bases -163 to +64). This promoter region was inserted into the promoterless pBLCAT3 plasmid, using the interleukin 1 alpha 5' fragment as the promoter to drive nerve growth factor inducible expression of the CAT (chloramphenicol acetyl transferase) reporter gene. Four mutants, with deletions of 9-15 bases in the 5' regulatory region of the human interleukin 1 alpha gene, were constructed: three...Continue Reading

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Citations

Apr 27, 2004·Periodontology 2000·John J TaylorPeter T Donaldson
Dec 17, 2017·Immunological Reviews·Ankit Malik, Thirumala-Devi Kanneganti
Aug 9, 2003·Journal of Endocrinological Investigation·M MinettoA Angeli
Jan 10, 2017·International Journal of Molecular Sciences·Michael J D Daniels, David Brough
Mar 11, 2020·Cell Research·Shelbi ChristgenThirumala-Devi Kanneganti
Jul 21, 2016·Nature Immunology·Nelson C Di Paolo, Dmitry M Shayakhmetov

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