PMID: 11325436Apr 28, 2001Paper

An apparatus and behavioral training protocol to conduct positron emission tomography (PET) neuroimaging in conscious rhesus monkeys

Journal of Neuroscience Methods
Leonard L HowellJ F Jordan

Abstract

Nonhuman primates offer a unique resource in neuroimaging research, providing the opportunity to manipulate appropriate biological and behavioral variables under well-controlled experimental conditions in an animal model that is closely related to humans, both functionally and neuroanatomically. The present report describes the development and standardization of PET neuroimaging protocols in conscious rhesus monkeys and their application to characterize the acute effects of cocaine on cerebral blood flow. Specific attention was devoted to the development of an effective and comfortable head restraint device to be used in the imaging of conscious monkeys. The restraint device was designed to attach to a standard primate chair to facilitate frequent immobilization. Subjects received extensive behavioral training prior to neuroimaging in order to ensure their comfort and minimize potential stress associated with the imaging protocols. Functional changes in cerebral blood flow were characterized in three subjects with the positron-emitting tracer 15O water following acute i.v. administration of cocaine. Regions of interest were defined on MRI scans with a high degree of accuracy. Cocaine caused pronounced increases in cerebral bloo...Continue Reading

References

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Citations

Nov 20, 2009·Psychopharmacology·Leonard L HowellKimberly P Lindsey
Sep 25, 2010·Psychopharmacology·Robert E HampsonSam A Deadwyler
Mar 2, 2011·Psychopharmacology·Kevin S Murnane, Leonard L Howell
Aug 4, 2010·Brain Imaging and Behavior·Porche' Kirkland HenryLeonard L Howell
Dec 18, 2008·Experimental and Clinical Psychopharmacology·Leonard L Howell
Jan 4, 2008·ILAR Journal·Michael A Nader, Paul W Czoty
Feb 15, 2011·The Journal of Pharmacology and Experimental Therapeutics·Leonard Lee Howell, Kevin Sean Murnane
Aug 26, 2009·Pharmacology, Biochemistry, and Behavior·Rayna M BauzoLeonard L Howell
Nov 11, 2008·Annals of the New York Academy of Sciences·Leonard L Howell, Kevin S Murnane
Feb 17, 2006·Methods : a Companion to Methods in Enzymology·Paul D GamlinDonald B Twieg
Nov 13, 2008·American Journal of Physical Anthropology·James K Rilling
Oct 15, 2013·NeuroImage·Fadila Hadj-BouzianeMartine Meunier
Feb 2, 2010·NeuroImage·Krishna SrihasamMargaret S Livingstone
Jan 26, 2013·Laboratory Animals·Aage Kristian Olsen Alstrup, Donald F Smith

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