An Apparent Deficiency of Lymphatic Capillaries in the Islets of Langerhans in the Human Pancreas

Diabetes
Erik Korsgren, Olle Korsgren

Abstract

The lymphatic system is crucial for efficient immune surveillance and for the maintenance of a physiological pressure in the interstitial space. Even so, almost no information is available concerning the lymph drainage of the islets of Langerhans in the human pancreas. Immunohistochemical staining allowed us to distinguish lymphatic capillaries from blood capillaries. Almost no lymphatic capillaries were found within the islets in pancreatic biopsy specimens from subjects without diabetes or from subjects with type 1 or type 2 diabetes. Lymphatic capillaries were, however, found at the islet-exocrine interface, frequently located along blood capillaries and other fibrotic structures within or close to the islet capsule. Lymphatic capillaries were regularly found in the exocrine pancreas, with small lymphatic vessels located close to and around acini. Larger collecting lymphatic vessels were located in fibrotic septa between the exocrine lobules and adjacent to the ductal system of the pancreas. In summary, we report a pronounced deficiency of lymphatic capillaries in human islets, a finding with implications for immune surveillance and the regulation of interstitial fluid transport in the endocrine pancreas as well as for the p...Continue Reading

References

Jul 1, 1966·The American Journal of the Medical Sciences·V BartosJ Groh
Jun 1, 1967·The Journal of Clinical Investigation·E A RasioG F Cahill
Jul 1, 1983·Diabetologia·L Jansson, C Hellerström
Feb 26, 1999·The Journal of Cell Biology·S BanerjiD G Jackson
Nov 1, 1958·Acta Endocrinologica·K BRUNFELDTA P SKOUBY
Mar 17, 2006·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·O KällskogL Jansson
Aug 11, 2010·Laboratory Investigation; a Journal of Technical Methods and Pathology·Anna PisaniaSusan Bonner-Weir
Oct 19, 2013·Science·Lulu XieMaiken Nedergaard
Aug 28, 2014·Clinics in Dermatology·Ada Lo SchiavoGabriella Brancaccio
Sep 11, 2014·Annals of Neurology·Benjamin T KressMaiken Nedergaard
Jan 1, 2014·Vascular Cell·Matthias S RoostSusana M Chuva de Sousa Lopes

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Citations

Oct 31, 2017·Diabetes, Obesity & Metabolism·Oskar Skog, Olle Korsgren

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