An appeal to magic? The discovery of a non-enzymatic metabolism and its role in the origins of life

The Biochemical Journal
Markus Ralser

Abstract

Until recently, prebiotic precursors to metabolic pathways were not known. In parallel, chemistry achieved the synthesis of amino acids and nucleotides only in reaction sequences that do not resemble metabolic pathways, and by using condition step changes, incompatible with enzyme evolution. As a consequence, it was frequently assumed that the topological organisation of the metabolic pathway has formed in a Darwinian process. The situation changed with the discovery of a non-enzymatic glycolysis and pentose phosphate pathway. The suite of metabolism-like reactions is promoted by a metal cation, (Fe(II)), abundant in Archean sediment, and requires no condition step changes. Knowledge about metabolism-like reaction topologies has accumulated since, and supports non-enzymatic origins of gluconeogenesis, the S-adenosylmethionine pathway, the Krebs cycle, as well as CO2 fixation. It now feels that it is only a question of time until essential parts of metabolism can be replicated non-enzymatically. Here, I review the 'accidents' that led to the discovery of the non-enzymatic glycolysis, and on the example of a chemical network based on hydrogen cyanide, I provide reasoning why metabolism-like non-enzymatic reaction topologies may h...Continue Reading

References

Jan 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·G Wächtershäuser
Jan 1, 1989·Free Radical Biology & Medicine·H W Gardner
May 1, 1969·Canadian Journal of Microbiology·N HowellR H Himes
Dec 1, 1968·Journal of Molecular Biology·F H Crick
Jul 3, 1999·Trends in Microbiology·M A HuynenP Bork
Nov 7, 1999·Archives of Microbiology·S J Cordwell
Jun 22, 2000·Proceedings of the National Academy of Sciences of the United States of America·H J MorowitzG D Cody
Oct 18, 2000·Nature·H JeongA L Barabási
Nov 1, 2000·Proceedings of the National Academy of Sciences of the United States of America·L E Orgel
Jan 1, 1985·Precambrian Research·J C Walker, P Brimblecombe
Feb 19, 2002·Chemical Reviews·W. Wallace ClelandGeorge H. Lorimer
Aug 19, 2003·The Biochemical Journal·Corné H VerheesJohn Van Der Oost
Jan 14, 2004·Genome Research·Anthony P BurgardCostas D Maranas
Feb 21, 2004·Science·Sandra Pizzarello, Arthur L Weber
Jun 26, 2004·Critical Reviews in Biochemistry and Molecular Biology·Leslie E Orgel
Jul 22, 2004·Journal of the American Chemical Society·Armando CórdovaJesús Casas
Jul 29, 2004·FEBS Letters·Kangmin Kim, Archie R Portis
Sep 2, 2004·Proceedings of the National Academy of Sciences of the United States of America·Eric Smith, Harold J Morowitz
Oct 21, 2004·Nature Reviews. Microbiology·Nathan D PriceBernhard Ø Palsson
Feb 19, 2005·Science·Olivier J RouxelKatrina J Edwards
Aug 30, 2005·Chemistry & Biology·Stefan FuszMichael Famulok
Jun 1, 1945·Proceedings of the National Academy of Sciences of the United States of America·N H Horowitz
Dec 15, 2006·Journal of the American Chemical Society·Xiang V Zhang, Scot T Martin
Apr 17, 2007·Molecular Cell·Elizabeth A VealBrian A Morgan
Jan 25, 2008·PLoS Biology·Leslie E Orgel
Sep 16, 2008·The International Journal of Biochemistry & Cell Biology·Gustavo Caetano-AnollésJay E Mittenthal
Jan 19, 2010·Proceedings of the National Academy of Sciences of the United States of America·Vera VasasMauro Santos
Jun 11, 2010·Cold Spring Harbor Perspectives in Biology·Antonio Lazcano
Oct 24, 2012·Nature Chemistry·Dougal Ritson, John D Sutherland
Nov 20, 2012·Chemistry & Biodiversity·Pier Luigi Luisi
Mar 5, 2013·Nature Biotechnology·Ines ThieleBernhard Ø Palsson
Apr 23, 2013·Chemistry & Biology·Nicholas V HudLoren Dean Williams
May 23, 2013·Nature Chemistry·Katarzyna Adamala, Jack W Szostak
Apr 1, 1990·Photosynthesis Research·B B Buchanan, D I Arnon
Mar 7, 2014·Microbiology and Molecular Biology Reviews : MMBR·Christopher BräsenBettina Siebers

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Citations

Oct 24, 2019·Interface Focus·Rafaela VasiliadouNick Lane
Mar 1, 2020·Life·Martina PreinerJoana C Xavier
Jun 21, 2020·British Journal of Pharmacology·Nicolas S MerleClaudia Kemper
Dec 13, 2018·Nature Communications·Stuart A Harrison, Nick Lane
Jan 31, 2019·Nature Ecology & Evolution·Markus A KellerMarkus Ralser
Oct 24, 2020·Nature Chemistry
Jul 21, 2020·Chemical Reviews·Kamila B MuchowskaJoseph Moran
Mar 16, 2019·Bioorganic & Medicinal Chemistry·Kamila B MuchowskaJoseph Moran
Jun 7, 2021·Biogerontology·Aleksei G Golubev
Apr 14, 2021·Annual Review of Plant Biology·Hiroshi A Maeda, Alisdair R Fernie
Aug 1, 2021·Acta Biotheoretica·Savio Torres de FariasGustavo Caponi
Aug 25, 2021·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Nino LauberKepa Ruiz-Mirazo
Nov 4, 2021·Journal of the American Chemical Society·Robert J MayerJoseph Moran

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