PMID: 11333409May 3, 2001Paper

An application of hierarchical regression in the investigation of multiple paternal occupational exposures and neuroblastoma in offspring

American Journal of Industrial Medicine
A J De RoosA F Olshan

Abstract

We used hierarchical regression to study the effects of 46 paternal occupational exposures on the incidence of neuroblastoma in offspring. The study population included 405 cases and 302 controls. The effect of each exposure was estimated using both conventional maximum likelihood and hierarchical regression. Using hierarchical regression, overall precision was greatly enhanced compared to the conventional analysis. In addition, adjustment of effect estimates based on prespecified prior distributions of the true effect parameters allowed a more consistent interpretation across the entire panel of exposures. Estimates for several metals and solvents were shrunk close to the null value, whereas estimates for several thinner solvents, diesel fuel, solders, wood dust, and grain dust remained moderately elevated. Hierarchical regression may mitigate some of the problems of the conventional approach by controlling for correlated exposures, enhancing the precision of estimates, and providing some adjustment of estimates based on prior knowledge.

References

Nov 1, 1994·Environmental Health Perspectives·S Greenland
Jan 1, 1994·Archives of Environmental Health·S Greenland, C Poole
Jun 15, 1996·Statistics in Medicine·J S Witte, S Greenland
Sep 8, 1998·Epidemiology·J S WitteL L Kim
Jan 5, 2000·Cancer Causes & Control : CCC·A F OlshanR P Castleberry
Apr 6, 2000·International Journal of Epidemiology·S Greenland
Oct 31, 2000·Epidemiology·J S WitteL Arab

❮ Previous
Next ❯

Citations

Sep 21, 2006·Journal of the National Cancer Institute·Ola LandgrenLynn R Goldin
Dec 26, 2006·Occupational and Environmental Medicine·H Kromhout, R Vermeulen
Mar 18, 2011·Movement Disorders : Official Journal of the Movement Disorder Society·Frédéric MoisanAlexis Elbaz
Oct 10, 2006·Journal of Clinical Epidemiology·Vincenzo BagnardiGiovanni Corrao
Jul 20, 2011·Journal of Psychosomatic Research·Perry M NicassioMichael H Weisman
Feb 3, 2007·Epidemiology·Richard F MacLehoseJane A Hoppin
Feb 24, 2009·Epidemiology·Suzan L CarmichaelGary M Shaw
Jun 14, 2005·Epidemiology·Stephanie A Mulherin EngelAndrew F Olshan
Feb 24, 2006·American Journal of Epidemiology·Rudolph P RullGary M Shaw

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.