An appraisal on recent medicinal perspective of curcumin degradant: Dehydrozingerone (DZG)

Bioorganic & Medicinal Chemistry
Girish A HampannavarMahamadhanif S Shaikh

Abstract

Natural products serve as a key source for the design, discovery and development of potentially novel drug like candidates for life threatening diseases. Curcumin is one such medicinally important molecule reported for an array of biological activities. However, it has major drawbacks of very poor bioavailability and solubility. Alternatively, structural analogs and degradants of curcumin have been investigated, which have emerged as promising scaffolds with diverse biological activities. Dehydrozingerone (DZG) also known as feruloylmethane, is one such recognized degradant which is a half structural analog of curcumin. It exists as a natural phenolic compound obtained from rhizomes of Zingiber officinale, which has attracted much attention of medicinal chemists. DZG is known to have a broad range of biological activities like antioxidant, anticancer, anti-inflammatory, anti-depressant, anti-malarial, antifungal, anti-platelet and many others. DZG has also been studied in resolving issues pertaining to curcumin since it shares many structural similarities with curcumin. Considering this, in the present review we have put forward an effort to revise and systematically discuss the research involving DZG with its biological divers...Continue Reading

References

Jun 2, 1998·Free Radical Biology & Medicine·K I PriyadarsiniM N Rao
Sep 2, 2000·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·R S RamsewakM G Nair
Jul 26, 2003·Journal of Natural Products·David J NewmanKenneth M Snader
Dec 13, 2005·Bioorganic & Medicinal Chemistry·Waylon M WeberDavid L Vander Jagt
Dec 27, 2008·Trends in Pharmacological Sciences·Bharat B Aggarwal, Bokyung Sung
Nov 10, 2010·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Natalie A KelseyDaniel A Linseman
Mar 6, 2012·Trends in Molecular Medicine·Liang Shen, Hong-Fang Ji
Jan 3, 2013·Journal of Food Science·I Rahath KubraL Jagan Mohan Rao
Feb 5, 2014·Journal of Food Science and Technology·Ismail Rahath KubraLingamallu Jagan Mohan Rao
Dec 31, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Dinesh ShettyJames P Snyder

❮ Previous
Next ❯

Citations

Jul 21, 2016·ACS Medicinal Chemistry Letters·Girish A HampannavarBalakumar Chandrasekaran
Dec 31, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Marco A Obregón-MendozaRaúl G Enríquez
Jun 18, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Sariya MapoungPornngarm Limtrakul Dejkriengkraikul
Aug 12, 2018·Journal of Cellular Biochemistry·Jamshid TabeshpourAmirhossein Sahebkar
Jan 29, 2019·Journal of Biomolecular Structure & Dynamics·Mahboobeh EslamiYounes Ghasemi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antimalarial Agents (ASM)

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Antimalarial Agents

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Antiparasitics

Antiparasitics are medications which are indicated for the treatment of parasitic diseases. Discover the latest research on antiparasitics here.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Related Papers

Anti-cancer Agents in Medicinal Chemistry
Wesam S AlwanRajshekhar Karpoormath
© 2022 Meta ULC. All rights reserved