An approach to comparative analysis of chromatographic fingerprints for assuring the quality of botanical drugs

Journal of Chemical Information and Computer Sciences
Yiyu ChengWeida Tong

Abstract

The present study was focused on developing the chemometric methods for analysis of the chromatographic fingerprint to control the quality of botanical drugs, which has gained attention in Asia and other countries. We developed a novel approach to generate a set of fingerprint features, called Fisher components (FCs) that were extracted from the chromatographic fingerprint. The method greatly reduces the dimensionality of the fingerprint vector, and the resulting FCs still retain most discriminatory information of the original fingerprint. Choosing an example of relevance to contemporary botanical drugs, we applied the FCs to a set of Shenmai injection samples. We successfully identified the manufacturers of the samples using two classifiers, linear discriminant analysis (LDA) and k-Nearest Neighbor (k-NN) based on the FCs. We also applied a similarity assessment together with the visual analysis using the FCs to exam the products from different manufacturers. We found that the lot-to-lot consistency of products can be accurately determined using the FCs. Finally, we demonstrated that the application of chemometric methods for chromatographic fingerprinting offers reliability to detect suspected fraud samples. In summary, we de...Continue Reading

Citations

Oct 15, 2008·Chinese Journal of Integrative Medicine·Ai-ping LuKe-ji Chen
Jun 17, 2006·Biomedical Chromatography : BMC·Famei LiZhigang Liu
Sep 28, 2005·Trends in Pharmacological Sciences·Wen-Yue Jiang
Dec 17, 2005·Journal of Pharmaceutical and Biomedical Analysis·Fan XiaohuiCheng Yiyu
Dec 20, 2005·Journal of Chromatography. a·Feng Gan, Runyi Ye
Jan 24, 2007·Rapid Communications in Mass Spectrometry : RCM·Eric C Y ChanHwee-Ling Koh
May 7, 2005·Canadian Journal of Physiology and Pharmacology·Yaw L SiowKarmin O

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