An Approach to Enhance Dissolution Rate of Tamoxifen Citrate

BioMed Research International
Nagaraja SreeHarshaGirish Meravanige

Abstract

We tested the solubility and dissolution of tamoxifen citrate to ascertain the optimal conditions for faster dissolution. Using the solvent evaporation method and hydrophilic carriers, we formulated tamoxifen citrate (TC) that contained solid dispersions (SDs). We increased the solubility and dissolution rate of TC with a solid dispersion system that consisted of polyethylene glycol (PEG-6000), beta-cyclodextrin (β-CD), and a combination of carriers. Physicochemical characteristics of solubility (mg/ml) were found to be 0.987±0.04 (water), 1.324±0.05 (6.8pH PBS), and 1.156±0.03 (7.4 pH PBS) for F5 formulation, percentage yield was between 98.74 ± 1.11% and 99.06 ± 0.58%, drug content was between 98.06±0.58 and 99.06±1.10, and dissolution studies binary complex showed a faster release of TC as compared to a single polymer and pure drug. Furthermore, thermal properties, physicochemical drug and polymer interaction, crystal properties, and morphology were determined using differential scanning calorimetry (DSC), infrared spectroscopy (FT-IR), X-ray differential studies, and scanning electron microscopy. We used the same proportion of carrier concentrations of the formulations to calculate the solubility of TC. Our results demonstr...Continue Reading

References

Oct 1, 1980·Molecular and Cellular Endocrinology·J L Borgna, H Rochefort
Jun 7, 2000·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·C Leuner, J Dressman
Nov 16, 2002·International Journal of Pharmaceutics·S VerheyenG Van den Mooter
Mar 7, 2006·International Journal of Pharmaceutics·Sang-Chul ShinXiuguo Li
Aug 4, 2006·Journal of Pharmaceutical Sciences·Charles M BuchananMichael F Wempe
Jul 3, 2007·Advanced Drug Delivery Reviews·Marcus E Brewster, Thorsteinn Loftsson
Dec 7, 2007·International Journal of Pharmaceutics·Takashi KojimaShuji Kitagawa
Mar 1, 2012·Journal of Pharmaceutical and Biomedical Analysis·Claudia GarneroMarcela Longhi
Jul 19, 2013·Current Drug Delivery·Punit BhatnagarDinesh Kumar Mishra
Aug 21, 2013·Saudi Pharmaceutical Journal : SPJ : the Official Publication of the Saudi Pharmaceutical Society·Jagadeesh G HiremathPrasanthkumar Mura
Oct 2, 2013·Indian Journal of Pharmaceutical Sciences·P T KohS Garg
Oct 5, 2013·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Ahmed Mohamed MagedDalia Ahmed Hamed
Nov 25, 2014·Advances in Experimental Medicine and Biology·Erem Bilensoy
Dec 6, 2017·Drug Development and Industrial Pharmacy·Klecia M Dos SantosFernanda Nervo Raffin
Oct 14, 2018·Acta Pharmacologica Sinica·Wen-Bo ZhouHao Li

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Citations

Mar 22, 2020·Journal of Bioenergetics and Biomembranes·Caroline Deckmann NicolettiVitor Francisco Ferreira

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Methods Mentioned

BETA
X-ray
Infrared Spectroscopy

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