Abstract
Antigenic relationships among three species of Aspergillus (A. fumigatus, A. glaucus, and A. flavus) were examined by paired cross-radioallergosorbent test (RAST) inhibition analysis, an in vitro technique based on human IgE antibody specificity. Alternaria tenuis was found to be antigenically unrelated to each of the three species of Aspergillus and was used as a negative control. A single test serum yielded uninhibited RAST indices of 6, 7.4, 8.1, and 7.8 for A. fumigatus, A. glaucus, A. flavus, and Alternaria tenuis, respectively. At a concentration of 10 mg/ml, A. fumigatus inhibited A. glaucus RAST by 63% and A. flavus RAST by 62%. A. glaucus inhibited A. fumigatus RAST by 36% and A. flavus RAST by 63%. A. flavus inhibited A. fumigatus RAST by 44% and A. glaucus RAST by 81%. Each species of Aspergillus produced significant but only partial inhibition of RAST to each of the other two species analyzed. Results indicate the existence of both shared and unique antigens among these three species of Aspergillus. Paired cross-RAST inhibition may be used as an approach to study species relationships among genera of several classes of clinically relevant fungi. Unless many strains are employed, data obtained do not represent a defi...Continue Reading
Citations
Jan 19, 1999·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·S LappalainenP Kalliokoski
Jul 1, 1996·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·A HelblingS B Lehrer
Sep 1, 1990·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·C E O'NeilS B Lehrer
Jun 1, 1995·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·B A Baldo
Jan 20, 1998·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·T KanbeA Ishiguro
Feb 1, 1993·Allergy·W E HornerS B Lehrer
May 1, 1994·Allergy·J Verma, S V Gangal
Mar 1, 1997·Allergy·P CullinanA J Taylor
May 23, 1998·Allergy·J VermaS V Gangal
May 9, 1998·Allergy·S van der HeideH F Kauffman
Mar 1, 1994·Occupational and Environmental Medicine·D M HalpinA J Newman Taylor
Jun 11, 2005·Allergologia et immunopathologia·H BouzianeB David
Oct 6, 2005·Archives of Environmental Health·Aristo Vojdani
Mar 1, 1987·Clinical Allergy·C E O'NeilS B Lehrer
May 1, 1988·Clinical Allergy·W E DavisS B Lehrer
Nov 1, 1985·Allergy·S van der HeideK de Vries
Apr 1, 1993·The Journal of Allergy and Clinical Immunology·J PortnoyC Barnes
Apr 1, 1991·The Journal of Allergy and Clinical Immunology·J PortnoyC Barnes
Oct 1, 1995·Allergy·J VermaS V Gangal
Nov 1, 1985·Allergy·S van der HeideK de Vries
Apr 1, 1995·Clinical Microbiology Reviews·W E HornerS B Lehrer
Jun 1, 1984·The Journal of Allergy and Clinical Immunology·S van der HeideK de Vries
Dec 1, 1988·The Journal of Allergy and Clinical Immunology·J D SprengerS B Lehrer