PMID: 6166856Mar 1, 1981Paper

An approach to modification of the repair activity in eucaryotic cells by biological factors

Mutation Research
G D ZasukhinaZ S Kirkova

Abstract

This work was devoted to investigation or repair regulation by biological factors: viruses and interferon. DNA damage induced by gamma- and UV-irradiation, ethyleneimine and 4-nitro-quinoline-1-oxide (4-NQO) were studied, by sedimentation of lysed cells through alkaline sucrose gradients, by hydroxylapatite column chromatography and by the chromosomal aberration test. The reproducible vaccinia virus resulted in simulation repair activity of chick embryo cells after treatment with 4-NQO. Interferon, added after gamma- and UV-irradiation, decreased the chromosomal aberration level, stabilized it after ethyleneimine treatment and also stimulated the ability of cells to rejoin DNA breaks induced by 4-NQO. The cause of this phenomenon is discussed.

Citations

Jan 1, 1983·Human Genetics·E Geissler, M Theile
Jan 1, 1985·Journal of Interferon Research·B R Jasny, I Tamm
May 1, 1996·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·S Tanneberger, P Hrelia
Apr 1, 1994·Pharmacology & Toxicology·P HreliaG Cantelli-Forti

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