An approach to multiobjective optimization of rotational therapy. II. Pareto optimal surfaces and linear combinations of modulated blocked arcs for a prostate geometry.

Medical Physics
Juan Pardo-Montero, John D Fenwick

Abstract

The purpose of this work is twofold: To further develop an approach to multiobjective optimization of rotational therapy treatments recently introduced by the authors [J. Pardo-Montero and J. D. Fenwick, "An approach to multiobjective optimization of rotational therapy," Med. Phys. 36, 3292-3303 (2009)], especially regarding its application to realistic geometries, and to study the quality (Pareto optimality) of plans obtained using such an approach by comparing them with Pareto optimal plans obtained through inverse planning. In the previous work of the authors, a methodology is proposed for constructing a large number of plans, with different compromises between the objectives involved, from a small number of geometrically based arcs, each arc prioritizing different objectives. Here, this method has been further developed and studied. Two different techniques for constructing these arcs are investigated, one based on image-reconstruction algorithms and the other based on more common gradient-descent algorithms. The difficulty of dealing with organs abutting the target, briefly reported in previous work of the authors, has been investigated using partial OAR unblocking. Optimality of the solutions has been investigated by comp...Continue Reading

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Citations

Mar 16, 2013·Artificial Intelligence in Medicine·Manuel Cruz-RamírezManuel de la Mata
Feb 11, 2014·Medical Physics·David CraftJan Unkelbach
Sep 21, 2011·Medical Physics·John D Fenwick, Juan Pardo-Montero
Apr 2, 2013·Medical Dosimetry : Official Journal of the American Association of Medical Dosimetrists·Jeremiah WalaJason Efstathiou
Jan 16, 2013·Journal of Applied Clinical Medical Physics·Ilma XhaferllariJeff Chen
Aug 4, 2018·The British Journal of Radiology·Mohammad HusseinAndrew Nisbet

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