An approach to quantitative assessment of hemodynamic differences between unruptured and ruptured ophthalmic artery aneurysms

Computer Methods in Biomechanics and Biomedical Engineering
Hongyu YuXinjian Yang

Abstract

Hemodynamic parameters are important in the pathogenesis, evolution and rupture of intracranial aneurysm. Energy loss (EL) has been applied for the rupture risk prediction of artery aneurysms recently. We proposed a new EL and further investigate its effects on the rupture of aneurysms. Sixty-four patient-specific ophthalmic aneurysm datasets were divided into ruptured and unruptured groups based on their clinical history. Based on patient-specific 3D-DSA data, realistic models were retrospectively reconstructed and then analyzed by using computational fluid dynamic method. The flow field feature EL in ruptured cases was significantly higher than that in unruptured cases. The average wall shear stress (WSS) and the maximum WSS in ruptured cases were higher than those in unruptured cases. Modified pressure loss coefficient (PLCM) in ruptured cases was slight higher than that in unruptured cases but the difference has no statistical significance. Multivariate logistic regression analysis demonstrated flow field feature EL (p < 0.05) and the maximum WSS (p < 0.05) were the only independently significant variables to predict rupture of ophthalmic aneurysm. There were no differences in PLCM, the maximum oscillatory shear index (OSI)...Continue Reading

References

Jan 1, 1980·Journal of Biomechanics·K HayashiK Moritake
Jan 17, 2002·Journal of Neurosurgery·H Richard WinnGavin W Britz
Mar 3, 2005·Journal of Neurosurgery·Madhavan L RaghavanRobert E Harbaugh
Mar 3, 2007·Stroke; a Journal of Cerebral Circulation·Marieke J H WermerGabriël J E Rinkel
Oct 11, 2008·Stroke; a Journal of Cerebral Circulation·Toshihiro IshibashiToshiaki Abe
Nov 26, 2010·Stroke; a Journal of Cerebral Circulation·Jianping XiangHui Meng
Jan 15, 2011·Stroke; a Journal of Cerebral Circulation·Bin LuoGuanghong Ding
Sep 10, 2011·AJNR. American Journal of Neuroradiology·Y QianY Murayama
Dec 3, 2011·European Neurology·Ying ZhangXinjian Yang
Mar 1, 2012·Stroke; a Journal of Cerebral Circulation·Hiroyuki TakaoToshiaki Abe
Jun 29, 2012·The New England Journal of Medicine·Akio MoritaTakashi Yoshimoto
Feb 13, 2013·European Journal of Radiology·F CaranciM Muto
Jul 23, 2013·Stroke; a Journal of Cerebral Circulation·Seppo JuvelaMatti Porras
Nov 21, 2013·Stroke; a Journal of Cerebral Circulation·Vitor Mendes PereiraRafik Ouared

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Citations

Mar 13, 2017·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Tianlun QiuHaitao Lu

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Software Mentioned

ANSYS CFX
EL

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