An approach to the diagnosis of spindle cell lesions of the breast

Histopathology
Emad A RakhaI O Ellis

Abstract

Although most breast spindle cell lesions (BSCLs) are rare, they constitute a wide spectrum of diseases, ranging from reactive processes to aggressive malignant tumours. Despite their varied histogenesis and behaviour, some lesions show an overlap of morphological features, making accurate diagnosis a challenging task, particularly in needle core biopsies. Clinical history and immunohistochemistry can help in making a correct diagnosis in morphologically challenging cases. To make an accurate diagnosis, it is important to maintain a wide differential diagnosis and be familiar with the diverse morphological appearances of these different entities. BSCLs can generally be classified into bland-looking and malignant-looking categories. In the former, the commonest diagnosis is scarring. However, it is important to distinguish low-grade spindle cell metaplastic breast carcinoma from other benign entities, as the management is clearly different. In the malignant category, it is important to differentiate metaplastic carcinoma from other malignant primary and metastatic malignant spindle cell tumours of the breast, such as malignant phyllodes tumour, angiosarcoma, and melanoma. This review focuses on the classification and histologica...Continue Reading

References

Jan 1, 1987·The American Journal of Surgical Pathology·E S WargotzF M Enzinger
May 1, 1969·American Journal of Clinical Pathology·B H Smith, H B Taylor
Jan 1, 1983·Virchows Archiv. A, Pathological Anatomy and Histopathology·D V Spagnolo, K B Shilkin
May 1, 1984·Cancer·M W KaufmanJ L Hoehn
Jan 1, 1994·Virchows Archiv : an International Journal of Pathology·S DamianiV Eusebi
Aug 1, 1997·Pathology·R Chetty, D Govender
Feb 9, 2000·American Journal of Clinical Pathology·H GobbiJ F Simpson
Jul 6, 2000·The Journal of Pathology·P PauwelsP Dal Cin
Aug 10, 2000·Histopathology·G MagroM Bisceglia
Mar 22, 2001·Australasian Radiology·J DahlstromS Jain
Jul 28, 2001·The American Journal of Surgical Pathology·N SneigeA Ayala
Nov 14, 2001·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·X WangK Kennichi
Feb 2, 2002·Human Pathology·Susan C AbrahamTsung-Teh Wu
Mar 1, 2003·Applied Immunohistochemistry & Molecular Morphology : AIMM·Jorge S Reis-FilhoFernando C Schmitt
Sep 19, 2003·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Helenice GobbiDavid L Page
Nov 2, 2005·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Ase K KlemmensenAnn Tabor
Jan 31, 2006·Journal of the European Academy of Dermatology and Venereology : JEADV·J GutermuthN Haas
Jun 2, 2006·The Journal of Pathology·J S Reis-FilhoF C Schmitt
Jun 21, 2006·Clinical Radiology·G J R PorterJ J James
Jul 20, 2007·Breast Cancer Research and Treatment·Gary M K TseThomas C Putti
Sep 21, 2007·Journal of Cell Science·Wenqing Xu, David Kimelman
Apr 17, 2008·Molecular Cancer Therapeutics·Judith A GilbertMatthew M Ames
Sep 25, 2008·The American Journal of Surgical Pathology·Alessandra F NascimentoChristopher D M Fletcher
Sep 26, 2008·Breast Cancer Research and Treatment·Britta WeigeltJorge S Reis-Filho
Dec 31, 2008·International Journal of Surgery·Timothy D Pencavel, Andrew Hayes
Jan 22, 2009·Pathology International·Tomo OsakoFutoshi Akiyama
Mar 14, 2009·International Journal of Surgical Pathology·Katja GwinFattaneh A Tavassoli
Jan 26, 2010·The Journal of Pathology·Felipe C GeyerJorge S Reis-Filho
Jun 23, 2010·Annals of Surgical Oncology·Amy C DegnimDaniel W Visscher
Aug 10, 2010·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Magali Lacroix-TrikiJorge S Reis-Filho
Aug 18, 2010·Proceedings of the National Academy of Sciences of the United States of America·Joseph H TaubeSendurai A Mani
Sep 4, 2010·Breast Cancer Research : BCR·Aleix PratCharles M Perou
Nov 30, 2010·Diagnostic Pathology·Aziza NassarAmy Degnim
Apr 5, 2011·The Journal of Pathology·Carolien H M van DeurzenEmad A Rakha
Aug 10, 2011·Laboratory Investigation; a Journal of Technical Methods and Pathology·Michele R Erickson-JohnsonAndre M Oliveira
Nov 19, 2011·International Journal of Surgery Case Reports·Marco MeleGiedrius Lelkaitis

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Citations

Dec 29, 2016·Histopathology·Emad A RakhaAndrew H S Lee
Sep 30, 2016·Clinical Chemistry·Marek H Dominiczak
Sep 11, 2019·Biotechnic & Histochemistry : Official Publication of the Biological Stain Commission·T BonachoJ Liberal
Nov 26, 2019·Archives of Pathology & Laboratory Medicine·Ellen G EastAndrew P Sciallis
May 26, 2017·AJR. American Journal of Roentgenology·Andrew S TaliaferroPriscilla J Slanetz
Aug 20, 2017·American Journal of Clinical Pathology·M Gabriela KubaJane E Brock
Mar 5, 2020·Diagnostic Pathology·Jasper VictoorGiuseppe Floris
Oct 3, 2018·Case Reports in Pathology·Emily HeroAbeer M Shaaban
Mar 18, 2021·Pathology International·Iskender Sinan GencoSabina Hajiyeva
Mar 27, 2021·Pathology, Research and Practice·Cao JinMansoor Nasim
May 7, 2021·Journal of Clinical Pathology·Siyuan ZhongWentao Yang
Nov 7, 2020·Indian Journal of Pathology & Microbiology·Siddhi Gaurish Sinai KhandeparkarBageshri Gogate
Jul 23, 2021·Virchows Archiv : an International Journal of Pathology·Stuart J SchnittThomas Decker
Jul 30, 2021·Virchows Archiv : an International Journal of Pathology·Emad A RakhaCecily Quinn

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