PMID: 9645992Jul 1, 1998Paper

An approach to understanding the mechanisms of poliovirus persistence in infected cells of neural or non-neural origin

Clinical and Diagnostic Virology
Florence Colbère-GarapinI Petit

Abstract

Poliovirus (PV) is the etiologic agent of paralytic poliomyelitis, which is sometimes followed, after decades of clinical stability, by new symptoms, including progressive muscular atrophy, collectively known as the post-polio syndrome. This raises the question of possible PV persistence in post polio patients. To test the capacity of PV to establish persistent infections in human cells, three models were developed. This review focuses on the viral and cellular parameters involved in persistent PV infection. Many PV strains, which are generally lytic in primate cell lines, are able to establish persistent infections in human neuroblastoma cells. During persistent infection, PV mutants (PVpi) are consistently selected, and several of their capsid substitutions occur at positions known to be involved in PV-PV receptor interactions. PVpi have a particular property: they can establish persistent infections in non-neural HEp-2 cells. PV can also persistently infect primary cultures of human fetal brain cells and the majority of cells which survive infection belong to the neuronal lineage. The results obtained with the three models of persistent PV infection in human cells suggest that several mechanisms are used by PV to establish a...Continue Reading

References

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Citations

Jun 20, 2001·Journal of Voice : Official Journal of the Voice Foundation·M M AbazaS Mandel
Apr 5, 2002·Journal of Virology·Ralph FeuerJ Lindsay Whitton
Jul 30, 2010·Therapeutics and Clinical Risk Management·Elisabeth Farbu
Mar 24, 2012·Future Microbiology·Hsing-I HuangShin-Ru Shih
Aug 31, 2012·Science China. Life Sciences·Qian LiQingHua Shi
May 14, 2008·Journal of the Neurological Sciences·Christopher B FordyceDaria A Trojan
May 6, 2015·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Andreina BajAntonio Toniolo
Apr 19, 2002·The Journal of General Virology·Sophie GirardBruno Blondel
Jan 22, 2011·Virology·Ross E RhoadesRalph Feuer
Mar 11, 2020·Frontiers in Microbiology·Bo-Shiun ChenShin-Ru Shih
May 23, 2006·Lancet Neurology·Henrik GonzalezKristian Borg

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