PMID: 9420709May 1, 1994Paper

An approach to ventricular efficiency by use of carbon 11-labeled acetate and positron emission tomography

Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology
H G WolpersM Schwaiger

Abstract

Positron emission tomography-derived 11C-labeled acetate kinetics have been shown to reflect myocardial oxidative metabolism. The objective of the study was to use this metabolic imaging technique in combination with an evaluation of left ventricular work as an index of ventricular mechanical efficiency. The effects of ventricular ejection fraction and loading on this index were studied quantitatively in a canine experimental model. There was a curvilinear relationship between efficiency and the end-diastolic volume per unit mass (r = 0.84), which appeared to integrate the main determinants of left ventricular mechanical performance successfully and allowed the detection of a decreased ventricular efficiency in acute experimental heart failure. This approach appears to have the potential to assess the energetic working point of the ventricle in clinical heart disease and follow the effects of therapy. The data demonstrate the feasibility of an estimate of ventricular efficiency that relies on noninvasive data-acquisition techniques.

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Jan 1, 1994·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·R S BeanlandsM Schwaiger

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Citations

Sep 3, 2010·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Franz BucheggerMaximilien Jung
Aug 22, 2006·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Marvin W KronenbergMarcelo F Di Carli
Jul 11, 2000·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·O Akinboboye, S R Bergmann
Dec 17, 2014·Current Cardiology Reports·Ali AhmadiLisa M Mielniczuk
May 6, 2016·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Claire S DuvernoyRodica Pop-Busui
Aug 7, 2007·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Linda R PetersonRobert J Gropler
Jan 30, 2009·American Journal of Physiology. Endocrinology and Metabolism·M'hamed BentourkiaStephen Cunnane
Aug 7, 2019·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Markus Schwaiger, Stephan G Nekolla

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