An approach towards development of monoclonal IgY antibodies against SARS CoV-2 spike protein (S) using phage display method: A review

International Immunopharmacology
Rajeswari SomasundaramMichael Antonysamy

Abstract

The present state of diagnostic and therapeutic developmental race for vaccines against the SARS CoV-2 (nCOVID-19) focuses on prevention and control of this global pandemic which also represents a critical challenge to the global health community. Although development of novel vaccines can prevent the SARS CoV-2 infections, it is still impeded by several other factors and therefore novel approaches towards treatment and management of this disease is the urgent need. Passive immunotherapy plays a vital role as a possible alternative to meet this challenge and among various antibody sources, chicken egg yolk antibodies (IgY) can be used as an alternative to mammalian antibodies which have been previously studied against SARS CoV outbreak in China. In this review, we discuss the strategies for the use of chicken egg yolk (IgY) antibodies in the development of rapid diagnosis and immunotherapy against SARS CoV-2. Also, IgY antibodies have previously been used against various respiratory bacterial and viral infections in humans and animals. Compared to mammalian antibodies (IgG), chicken egg yolk antibodies (IgY) have greater binding affinity to specific antigens, ease of extraction and lower production costs, hence possessing remar...Continue Reading

Citations

Sep 3, 2020·Vaccines·José M Pérez de la LastraAntonio Morales-delaNuez
Nov 3, 2020·Journal of Immunology Research·Yan LuWen Wang
Oct 17, 2020·Human Vaccines & Immunotherapeutics·Rabeea SiddiqueSuliman Khan
Jun 29, 2021·Frontiers in Immunology·Lucia LeeDaria Mochly-Rosen
Jun 29, 2021·Advanced Therapeutics·Pratik AdhikaryKun Cheng
Aug 21, 2021·International Journal of Biological Macromolecules·Mayara Torquato Lima da SilvaLivia Melo Villar
Aug 24, 2021·Applied Microbiology and Biotechnology·Hilal Ahmad ParrayRajesh Kumar
Oct 28, 2021·Journal of Applied Microbiology·Lirong BaoYan Li
Jan 7, 2022·Journal of Agricultural and Food Chemistry·Leina DouZhanhui Wang

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Methods Mentioned

BETA
phage display
PCR
ELISA

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