An aqueous-based process to bioactivate poly(ε-caprolactone)/mesoporous bioglass composite surfaces by prebiotic chemistry-inspired polymer coatings for biomedical applications.

Colloids and Surfaces. B, Biointerfaces
Sheng-Ying ChengShiao-Wen Tsai

Abstract

Despite the wide use of aliphatic polyesters, such as poly(L-lactic acid) (PLLA) and poly(ε-caprolactone) (PCL), for many biomedical applications, these materials are limited due to their hydrophobic properties and lack of functional groups to bond with ligands to enhance the cell reorganization. Recently, a composite consisting of bioglass and PCL was demonstrated to enhance the mechanical strength and to improve the degradation rate. Although numerous approaches have been developed to improve the wettability of aliphatic polyesters to create a favorable interface with cells, only few surface modification methods can be independently applied to surfaces with different material. In this work, mesoporous bioglass (MBG) nanoparticles embedded in PCL films were modified by the polymerization of aminomalonitrile (AMN) with 3,4,5-trihydroxybenzaldehyde (THBA). The copolymer layer was further utilized as a mediator to conjugate chitosan and evaluate the antibacterial efficacy. Our results show that the hydrophilicity of the composite membranes significantly improved after treatment. In addition, after immersion in simulated body fluid (SBF) for 14 days, hydroxyapatite formation was only observed on the treated membranes. This result ...Continue Reading

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