PMID: 9420283Jan 7, 1998Paper

An arenavirus RING (zinc-binding) protein binds the oncoprotein promyelocyte leukemia protein (PML) and relocates PML nuclear bodies to the cytoplasm

Journal of Virology
K L BordenM S Salvato

Abstract

The promyelocytic leukemia protein (PML) forms nuclear bodies which are altered in some disease conditions. We report that the cytoplasmic RNA virus lymphocytic choriomeningitis virus (LCMV) influences the distribution of PML bodies. In cells infected with LCMV, the Z protein and PML form large bodies primarily in the cytoplasm. Transient transfection studies indicate that Z alone is sufficient to redistribute PML to the cytoplasm and that PML and Z colocalize. Coimmunoprecipitation studies show specific interaction between PML and Z proteins. A similar result was observed with a Z protein from another arenavirus, Lassa virus, suggesting that this is a general feature of the Arenaviridae. Genetically engineered mutations in PML were used to show that the Z protein binds the N-terminal region of PML and does not need the PML RING or the nuclear localization signal to colocalize. The Z protein acts dominantly to overcome the diffuse phenotype observed in several PML mutants. The interaction between PML and Z may influence certain unique characteristics of arenavirus infection.

References

Jan 1, 1975·Intervirology·S N BanerjeeW E Rawls
Sep 1, 1992·Trends in Biochemical Sciences·B A ReddyP S Freemont
Mar 1, 1991·The Journal of Cell Biology·C A Ascoli, G G Maul
Jan 1, 1986·Cold Spring Harbor Symposia on Quantitative Biology·K MullisH Erlich
Nov 1, 1995·The Journal of General Virology·C KellyG W Wilkinson
Jan 5, 1996·The Journal of Biological Chemistry·X F LeK S Chang
Oct 1, 1995·Mammalian Genome : Official Journal of the International Mammalian Genome Society·A D GoddardE Solomon
Feb 20, 1996·Proceedings of the National Academy of Sciences of the United States of America·K L BordenP S Freemont
Aug 1, 1996·The Journal of Cell Biology·A M Ishov, G G Maul
Jun 1, 1996·Current Opinion in Structural Biology·K L Borden, P S Freemont

❮ Previous
Next ❯

Citations

Mar 22, 2002·Journal of Virology·Weldy V BonillaHans Hengartner
Sep 13, 2003·Journal of Virology·Rodrigo JácamoMaría T Franze-Fernández
Oct 18, 2003·Proceedings of the National Academy of Sciences of the United States of America·Mar PerezJuan C de la Torre
Feb 24, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sylvain BaizeVincent Deubel
May 30, 2008·PloS One·Beth A McNallyPan Zheng
Jan 29, 2010·Journal of Virology·Allison GrosethStephan Becker
Jan 25, 2013·Viruses·Magali E Droniou-Bonzom, Paula M Cannon
Nov 30, 2013·Journal of Cellular Biochemistry·Guoxiang JinHui-Kuan Lin
Jul 19, 2013·Journal of Virology·Sabrina Schreiner, Harald Wodrich
Jul 19, 2002·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Christopher H Eskiw, David P Bazett-Jones
Sep 29, 2004·Journal of Virology·Mar PerezJuan Carlos de la Torre
Oct 19, 2004·Critical Reviews in Clinical Laboratory Sciences·Stephan Günther, Oliver Lenz
Dec 19, 2002·International Reviews of Immunology·Christopher F Basler, Adolfo García-Sastre
May 13, 2006·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Mounira K Chelbi-AlixDanielle Blondel
Oct 30, 2008·Biomolecular NMR Assignments·Laurent VolponKatherine L B Borden
Sep 22, 2005·Nature Reviews. Microbiology·Sébastien NisoleAli Saïb
Jan 21, 2011·Journal of Virology·Olena ShtankoYoshihiro Kawaoka
Dec 4, 2012·Viruses·Nadezhda E Yun, David H Walker
Nov 6, 2012·BMC Biotechnology·Cristina S BorioMario E Lozano
May 22, 2003·The Journal of Biological Chemistry·Xiaolong WeiCarl G Maki
Jan 17, 2002·Proceedings of the National Academy of Sciences of the United States of America·Alex KentsisKatherine L B Borden
Mar 3, 2004·Journal of Virology·Tatjana I CornuJuan Carlos de la Torre
Jul 24, 2010·Journal of Biomedicine & Biotechnology·S E GoñiM E Lozano
May 23, 2012·Expert Opinion on Drug Discovery·Sheli R RadoshitzkySina Bavari

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.