An artificial intelligence decision support system for the management of type 1 diabetes.

Nature Metabolism
Nichole S TylerPeter G Jacobs

Abstract

Type 1 diabetes (T1D) is characterized by pancreatic beta cell dysfunction and insulin depletion. Over 40% of people with T1D manage their glucose through multiple injections of long-acting basal and short-acting bolus insulin, so-called multiple daily injections (MDI)1,2. Errors in dosing can lead to life-threatening hypoglycaemia events (<70 mg dl-1) and hyperglycaemia (>180 mg dl-1), increasing the risk of retinopathy, neuropathy, and nephropathy. Machine learning (artificial intelligence) approaches are being harnessed to incorporate decision support into many medical specialties. Here, we report an algorithm that provides weekly insulin dosage recommendations to adults with T1D using MDI therapy. We employ a unique virtual platform3 to generate over 50,000 glucose observations to train a k-nearest neighbours4 decision support system (KNN-DSS) to identify causes of hyperglycaemia or hypoglycaemia and determine necessary insulin adjustments from a set of 12 potential recommendations. The KNN-DSS algorithm achieves an overall agreement with board-certified endocrinologists of 67.9% when validated on real-world human data, and delivers safe recommendations, per endocrinologist review. A comparison of inter-physician-recommende...Continue Reading

Associated Clinical Trials

References

Aug 19, 2008·Journal of Process Control·Cesar C PalermFrancis J Doyle
Feb 11, 2010·Journal of Diabetes Science and Technology·Howard ZisserLois Jovanovic
Apr 24, 2012·Journal of Diabetes and Its Complications·Eran Bashan, Israel Hodish
Nov 15, 2013·Journal of Medical Internet Research·Morwenna KirwanMitch J Duncan
May 31, 2014·Journal of Diabetes Science and Technology·Chiara Dalla ManClaudio Cobelli
May 23, 2015·Diabetes Care·Kellee M MillerUNKNOWN T1D Exchange Clinic Network
Feb 11, 2016·Diabetes Care·UNKNOWN Diabetes Control and Complications Trial (DCCT)/Epidemiology of Diabetes Interventions and Complications (EDIC) Study Resear
Aug 18, 2016·Journal of Diabetes Science and Technology·Jeremy Pettus, Steven V Edelman
Aug 31, 2016·Diabetes Spectrum : a Publication of the American Diabetes Association·G Blair Sarbacker, Elizabeth M Urteaga
Jan 25, 2017·JAMA : the Journal of the American Medical Association·Roy W BeckUNKNOWN DIAMOND Study Group
Jul 19, 2017·Diabetes, Obesity & Metabolism·Ravi ReddyPeter G Jacobs
Feb 1, 2018·Clinical Diabetes : a Publication of the American Diabetes Association·Mayer B DavidsonMartin Lee
Mar 2, 2018·Journal of Diabetes Science and Technology·Pau HerreroPantelis Georgiou
Mar 2, 2018·Journal of Diabetes Science and Technology·Carmen Pérez-GandíaM Elena Hernando
May 10, 2018·Journal of General Internal Medicine·Stephanie VeazieMark Helfand

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Citations

Sep 11, 2020·Nature Medicine·Samantha Cruz RiveraUNKNOWN SPIRIT-AI and CONSORT-AI Consensus Group
Sep 11, 2020·BMJ : British Medical Journal·Samantha Cruz RiveraUNKNOWN SPIRIT-AI and CONSORT-AI Working Group
Sep 11, 2020·Nature Medicine·Xiaoxuan LiuUNKNOWN SPIRIT-AI and CONSORT-AI Working Group
Sep 11, 2020·BMJ : British Medical Journal·Xiaoxuan LiuUNKNOWN SPIRIT-AI and CONSORT-AI Working Group
Jun 11, 2020·Sensors·Nichole S Tyler, Peter G Jacobs
Oct 14, 2020·Diabetes Technology & Therapeutics·Parizad AvariMonika Reddy
Dec 18, 2020·The Lancet. Digital Health·Samantha Cruz RiveraUNKNOWN SPIRIT-AI and CONSORT-AI Working Group
Apr 3, 2021·Journal of Translational Medicine·Ammira Al-Shabeeb AkilKhalid A Fakhro
Apr 18, 2021·The Lancet. Diabetes & Endocrinology·Sam N ScottUNKNOWN study of Integrative Biology of Exercise in diabetes
May 7, 2021·Clinical & Experimental Ophthalmology·Hussein IbrahimAlastair K Denniston
Jun 2, 2021·Diabetes Technology & Therapeutics·Revital NimriMoshe Phillip
Aug 16, 2021·Journal of Cardiac Surgery·Scott M Pappada

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Clinical Trials Mentioned

NCT03443713

Software Mentioned

InPen
ABC4D
Padova
UVA
ALPHA
DSS
OHSU T1D simulator
Padova simulator
KNN

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