An artificial intelligent diagnostic system with neural networks to determine genetical disorders and fetal health by using maternal serum markers

European Journal of Obstetrics, Gynecology, and Reproductive Biology
M S BeksaçY Laleli

Abstract

To develop an artificial intelligent diagnostic system with neural networks to determine genetical disorders and fetal health problems by using maternal serum markers ('Triple Test') and maternal age. A total of 112 pregnant women were referred to Fetal Medicine Unit of Hacettepe University Hospital for fetal ultrasonography and chromosome analysis with different indications. All patients underwent genetic amniocentesis or fetal blood sampling under ultrasound guidance. Gross malformations and hydrops fetalis were detected in 15 and 5 fetuses, respectively. We have found chromosomal abnormality in 7 cases. 'Triple Test' is offered to all patients and serum levels of alpha-fetoprotein, human chorionic gonadotropin and unconjugated estriol were analyzed by radioimmunoassay. In this study, we have used supervised artificial neural network structure to develop a diagnostic system. Our system's input parameters are maternal age, gestational age and 'Triple Test' results. Our system consists of two different artificial neural network modules whose decision-making logics are different. One of them is designed to search genetical disorders while the other one is for the assessment of fetal well-being. Confusion matrix is used for stati...Continue Reading

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Citations

Dec 3, 2003·Prostaglandins, Leukotrienes, and Essential Fatty Acids·E StachowskaR Turowski
Feb 10, 2009·Computers in Biology and Medicine·Babita Pandey, R B Mishra
Feb 13, 2016·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Mehmet ÇakarM Sinan Beksaç
Jun 1, 1996·Baillière's Clinical Obstetrics and Gynaecology·H P Van Geijn
Mar 29, 2006·Journal of Renal Nutrition : the Official Journal of the Council on Renal Nutrition of the National Kidney Foundation·Ewa StachowskaDariusz Chlubek
Nov 27, 2018·Technology and Health Care : Official Journal of the European Society for Engineering and Medicine·H Ozge BacakMehmet Sinan Beksac

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