PMID: 4897201Jun 1, 1969Paper

An aspartic acid residue at the active site of pepsin. The isolation and sequence of the heptapeptide

The Biochemical Journal
R S BaylissG B Wybrandt

Abstract

Pepsin reacts stoicheiometrically with the active-site-directed irreversible inhibitor N-diazoacetyl-l-phenylalanine methyl ester, with concomitant loss of all proteolytic and peptidolytic activity. The reagent esterifies a unique aspartic acid residue in pepsin, which is in the sequence:Ile-Val-Asp-Thr-Gly-Thr-Ser

Citations

Jan 1, 1983·Clinical and Experimental Hypertension. Part A, Theory and Practice·K S MisonoT Inagami
Jun 15, 1973·European Journal of Biochemistry·L F MatyashV M Stepanov
Nov 1, 1970·European Journal of Biochemistry·G K Garg, T K Virupaksha
Jan 1, 1980·Annals of the New York Academy of Sciences·S H HixsonE K Novak
Oct 16, 2016·ACS Chemical Biology·Kalie A MixRonald T Raines
Nov 24, 1970·Biochemistry·J L Denburg, W D McElroy
Jun 10, 1980·Biochemistry·K S Misono, T Inagami
Aug 29, 1980·Biochemical and Biophysical Research Communications·R L Johnson, A M Poisner
Jul 30, 1981·Biochemical and Biophysical Research Communications·S NakayamaM Yoshida
Jul 15, 1974·FEBS Letters·L Morávek, V Kostka
Sep 7, 1970·FEBS Letters·H Keilová, C Lapresle
Sep 1, 1971·FEBS Letters·T M. Kitson, J R. Knowles
Sep 15, 1973·FEBS Letters·L Morávek, V Kostka
Jun 24, 2008·Journal of Enzyme Inhibition and Medicinal Chemistry·Hisashi ItoKenji Takahashi
Apr 1, 1982·CRC Critical Reviews in Biochemistry·M L Sinnott
Jan 1, 1989·The International Journal of Biochemistry·K IkedaS Nakagawa
Sep 25, 1999·Journal of the American Society for Mass Spectrometry·P A GuyB W Erickson
Jan 23, 1974·Biochemical and Biophysical Research Communications·T InagamiA M Michelakis
Oct 1, 1970·Archives of Biochemistry and Biophysics·Y Nakagawa, G E Perlmann
Nov 15, 1972·Biochemical and Biophysical Research Communications·G G KovalevaV M Stepanov
Dec 25, 1975·Journal of Molecular Biology·J A JenkinsL Ungaretti

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