An assay for circulating antibodies to a major etiologic virus of human non-A, non-B hepatitis

Science
G KuoC E Stevens

Abstract

A specific assay has been developed for a blood-borne non-A, non-B hepatitis (NANBH) virus in which a polypeptide synthesized in recombinant yeast clones of the hepatitis C virus (HCV) is used to capture circulating viral antibodies. HCV antibodies were detected in six of seven human sera that were shown previously to transmit NANBH to chimpanzees. Assays of ten blood transfusions in the United States that resulted in chronic NANBH revealed that there was at least one positive blood donor in nine of these cases and that all ten recipients seroconverted during their illnesses. About 80 percent of chronic, post-transfusion NANBH (PT-NANBH) patients from Italy and Japan had circulating HCV antibody; a much lower frequency (15 percent) was observed in acute, resolving infections. In addition, 58 percent of NANBH patients from the United States with no identifiable source of parenteral exposure to the virus were also positive for HCV antibody. These data indicate that HCV is a major cause of NANBH throughout the world.

Associated Clinical Trials

References

Apr 10, 1975·The New England Journal of Medicine·S M FeinstoneP V Holland
Apr 15, 1989·Annals of Internal Medicine·M J Alter
Feb 1, 1986·Seminars in Liver Disease·J L Dienstag, H J Alter
Aug 23, 1984·The New England Journal of Medicine·C E StevensW Szmuness
Jan 1, 1983·Vox Sanguinis·J M HernándezJ Triginer
Dec 9, 1982·The New England Journal of Medicine·W SzmunessA Kellner
Jun 1, 1982·The Journal of Infectious Diseases·M J AlterG M Matanoski

❮ Previous
Next ❯

Citations

Mar 1, 1996·Journal of Medical Virology·D MoradpourJ R Wands
Mar 1, 1996·Journal of Medical Virology·N YukiT Kamada
Apr 1, 1996·Journal of Medical Virology·T J Pilot-MatiasI K Mushahwar
Jul 1, 1996·Journal of Medical Virology·A O Oni, T J Harrison
Oct 1, 1996·Journal of Medical Virology·A Fournillier-JacobC Wychowski
Aug 1, 1997·Journal of Medical Virology·A BenaniA Benslimane
Jan 4, 1998·Journal of Medical Virology·H M HassobaT L Wright
Feb 18, 1999·Journal of Medical Virology·M MonazahianR Thomssen
Sep 29, 1999·Journal of Medical Virology·A HondaT Tokuhisa
Jan 1, 1996·Journal of Clinical Laboratory Analysis·D LavanchyP C Frei
Feb 16, 2000·Journal of Peptide Science : an Official Publication of the European Peptide Society·N J EdeS Rosenberg
Jun 1, 1996·Reviews in Medical Virology·T J Harrison
Jun 10, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M HattoriS Kakumu
Jul 10, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·D MoradpourH E Blum
Sep 10, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M CharltonJ Hoofnagle
Oct 2, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·D T LauJ H Hoofnagle
Oct 2, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·T FukumaC Sato
May 29, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·T KandaH Saisho
Jul 27, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A SakaiK Kobayashi
Jan 1, 1994·Journal of Clinical Laboratory Analysis·R A McPherson
Jul 13, 2002·Journal of Medical Virology·Qian CaiZhiMeng Lu

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.