An assessment of adverse drug reactions among HIV positive patients receiving antiretroviral treatment in South Africa

AIDS Research and Therapy
Lieketseng J MasenyetseHenry G Mwambi

Abstract

Antiretroviral treatment (ART) has been effective in reducing HIV/AIDS related morbidity and mortality. However, the use and uptake of ART has resulted in adverse reactions, due mainly to the medicine's toxicity and interactions with other medicines. The timing of adverse drug reactions (ADRs) among these patients is a critical public health issue for antiretroviral (ARV) treatment adherence and retention. Reliable monitoring of HIV patients on ART is through a structured pharmacovigilance surveillance system. However, recurrent nature of these data pose challenges in their analyses. This study aimed at modelling the timing of ADR events in HIV patients on ART using correlated time-to-event models. The data concern 590 HIV patients registered onto the Medunsa National ARV Pharmacovigilance Surveillance System within 6 months of ART initiation between February 2007 and July 2011. Recurrent times of ADRs and baseline characteristics: patient gender, and age, ART regimen, clinic and initiation period were extracted from the data. The recurrent ADR events data were modelled using both shared frailty and marginal models on the five patients' characteristics as covariates. Out of 590 patients, 67% were female, 68% started on regimen:...Continue Reading

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Citations

Jun 18, 2016·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Marita MannAndy Stergachis
Jul 29, 2016·Journal of Zoo and Wildlife Medicine : Official Publication of the American Association of Zoo Veterinarians·Matthew E Kinney, Geoffrey W Pye
Mar 10, 2017·Virulence·Marco RipaGiuseppe Tambussi
Oct 30, 2020·HIV/AIDS : Research and Palliative Care·Esileman Abdela MucheMohammed Biset Ayalew

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