An assessment of histological margins and recurrence of melanoma in situ

Plastic and Reconstructive Surgery. Global Open
Kenneth M JoyceJack L Kelly

Abstract

Melanoma in situ (MIS) accounts for up to 27% of all melanomas. MIS has no metastatic potential and the aim should be to excise the lesion completely with a clear histological margin, although margin clearance remains undefined. We aimed to assess the relation of histological excision margins of MIS to recurrence and progression to invasive disease. We analyzed all patients with MIS excised by wide local excision or staged excision in our institution over a 5-year period from December 2008 to January 2014 using a prospectively maintained database. Clinicopathologic details included patient demographics, anatomical site of lesion, melanoma subtype, histological excision margin, and recurrence. A total of 410 patients had MIS excised during this time, the majority of which were lentigo maligna subtype (79%). The average histological excision margin was 3.7 mm. The rate of recurrence was 2.2% (9/410), with a median follow-up of 23 months. Lentigo maligna had a similar rate of recurrence to non-lentigo MIS (2.3% vs 1.2%) (P = 0.69). The mean excision margin of those that recurred was 1.9 mm compared with an average of 3.8 mm in those that did not. The rate of recurrence of MIS with histological excision margin ≤3.00 mm was 3.8% com...Continue Reading

References

Jul 23, 1998·Journal of the American Academy of Dermatology·D L ShrinerR F Wagner
Jun 12, 2002·Lancet·Mosaad MegahedMichael P Schön
Oct 26, 2002·Journal of the American Academy of Dermatology·Neera Agarwal-AntalJohn W Gerwels
May 19, 2004·Archives of Dermatology·Jennifer L BubPeter B Odland
Sep 24, 2004·Archives of Dermatology·Shyamala C HuilgolRaman Malhotra
Jan 1, 2005·Journal of the American Academy of Dermatology·Gregory M BriccaJohn A Zitelli
Jan 18, 2006·Cancer Causes & Control : CCC·Michael CooryIan Ring
Jul 4, 2008·Cancer Control : Journal of the Moffitt Cancer Center·Graham S ClarkL Frank Glass
Jul 9, 2010·The British Journal of Dermatology·J R MarsdenUNKNOWN British Association of Dermatologists Clinical Standards Unit
Jul 30, 2010·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·James R DeBloomDavid G Brodland
Dec 27, 2011·Journal of the American Academy of Dermatology·Joy H KunishigeJohn A Zitelli
Jan 22, 2013·CA: a Cancer Journal for Clinicians·Rebecca SiegelAhmedin Jemal
Jan 22, 2014·Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS·S AkhtarP R W Stanley
Jan 1, 2014·Healthcare·Solmaz Niknam LeilabadiAlex K Wong

❮ Previous
Next ❯

Citations

Dec 15, 2015·Journal of Surgical Oncology·Cecilia G Ethun, Keith A Delman
Mar 16, 2017·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Karen L ConnollyKishwer S Nehal
May 1, 2017·Melanoma Management·Brian D WernickJeffrey M Farma
Oct 24, 2019·Anais Brasileiros De Dermatologia·Andressa GermanoGilles Landman
Jan 1, 2019·Anais Brasileiros De Dermatologia·Andressa GermanoGilles Landman
Nov 13, 2020·Journal of Skin Cancer·Francisco S MouraStuart W McKirdy
Oct 8, 2020·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·Gareth CrouchSydney Ch'ng
Jul 29, 2021·The Journal of Dermatological Treatment·R KwakH C Tsibris

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved